PMID- 22306512
OWN - NLM
STAT- MEDLINE
DCOM- 20120511
LR  - 20171116
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 143
IP  - 1
DP  - 2012 Apr
TI  - Demethylation of TNFSF7 contributes to CD70 overexpression in CD4+ T cells from 
      patients with systemic sclerosis.
PG  - 39-44
LID - 10.1016/j.clim.2012.01.005 [doi]
AB  - The pathogenesis of systemic sclerosis (SSc) is still unclear. CD70, a B cell 
      costimulatory molecule that interacts with CD27 during B-T cell contact, is 
      overexpressed due to demethylation of its promoter regulatory elements in CD4+ T 
      cells from patients with the following autoimmune diseases, namely systemic lupus 
      erythematosus (SLE), subacute cutaneous lupus erythematosus (SCLE) and primary 
      Sjogren's syndrome (pSS). However, as an autoimmune disease, it is unknown 
      whether aberrant expression and methylation of CD70 occur in SSc CD4+ T cells. We 
      aimed to investigate whether the aberrant expression and methylation status of 
      CD70 occur in CD4+ T cells from patients with SSc. We found that the CD70 is 
      overexpressed and the CD70 promoter region is demethylated in SSc CD4+ T cells. 
      These findings suggest that demethylation of CD70 promoter region contributes to 
      the overexpression of CD70 in CD4+ T cells and may contribute to autoimmune 
      response in SSc.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Jiang, HongYan
AU  - Jiang H
AD  - Department of Dermatology, Second Xiangya Hospital, Central South University, 139 
      Ren-Min Road, Changsha 410011, China.
FAU - Xiao, Rong
AU  - Xiao R
FAU - Lian, XiaoRi
AU  - Lian X
FAU - Kanekura, Takuro
AU  - Kanekura T
FAU - Luo, YangYang
AU  - Luo Y
FAU - Yin, YongXing
AU  - Yin Y
FAU - Zhang, GuiYing
AU  - Zhang G
FAU - Yang, Yan
AU  - Yang Y
FAU - Wang, YaoYao
AU  - Wang Y
FAU - Zhao, Ming
AU  - Zhao M
FAU - Lu, QianJin
AU  - Lu Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120118
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (CD27 Ligand)
RN  - 0 (CD70 protein, human)
RN  - 0 (RNA, Messenger)
SB  - IM
CIN - Clin Immunol. 2012 Apr;143(1):1-3. PMID: 22386864
MH  - Adult
MH  - CD27 Ligand/*genetics/immunology
MH  - CD4-Positive T-Lymphocytes/immunology/*metabolism
MH  - Cells, Cultured
MH  - DNA Methylation/*genetics/immunology
MH  - Female
MH  - Gene Expression Regulation/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Promoter Regions, Genetic/genetics
MH  - RNA, Messenger/genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Scleroderma, Systemic/*genetics/immunology
MH  - Young Adult
EDAT- 2012/02/07 06:00
MHDA- 2012/05/12 06:00
CRDT- 2012/02/07 06:00
PHST- 2011/10/03 00:00 [received]
PHST- 2011/12/31 00:00 [revised]
PHST- 2012/01/10 00:00 [accepted]
PHST- 2012/02/07 06:00 [entrez]
PHST- 2012/02/07 06:00 [pubmed]
PHST- 2012/05/12 06:00 [medline]
AID - S1521-6616(12)00009-5 [pii]
AID - 10.1016/j.clim.2012.01.005 [doi]
PST - ppublish
SO  - Clin Immunol. 2012 Apr;143(1):39-44. doi: 10.1016/j.clim.2012.01.005. Epub 2012 
      Jan 18.