PMID- 22306689
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120912
LR  - 20220318
IS  - 2157-3999 (Electronic)
IS  - 2157-3999 (Linking)
VI  - 4
DP  - 2012 Jan 25
TI  - Percent-predicted 6-minute walk distance in duchenne muscular dystrophy to 
      account for maturational influences.
PG  - RRN1297
LID - RRN1297
AB  - We recently described a modified version of the 6-minute walk test (6MWT) for 
      Duchenne muscular dystrophy (DMD) based partly on the American Thoracic Society 
      (ATS) guidelines. This measure has shown reliability, validity and utility as a 
      primary outcome measure in DMD clinical trials. Because loss of muscle function 
      in DMD occurs against the background of normal childhood growth and development, 
      younger children with DMD can show increase in distance walked during 6MWT over 
      ~1 year despite progressive muscular impairment. In this study, we compare 
      6-minute walk distance (6MWD) data from DMD boys (n=17) and typically developing 
      control subjects (n=22) to existing normative data from age- and sex-matched 
      children and adolescents. An age- and height-based equation fitted to normative 
      data by Geiger and colleagues was used to convert 6MWD to a percent-predicted 
      (%-predicted) value in boys with DMD. Analysis of %-predicted 6MWD data 
      represents a method to account for normal growth and development, and shows that 
      gains in function at early ages represents stable rather than improving abilities 
      in boys with DMD. Boys with DMD from 4-7 years of age maintain a stable 6MWD 
      approximately 80% of that of typically developing peers, with the deficit 
      progressing at a variable rate thereafter.
FAU - Henricson, Erik
AU  - Henricson E
AD  - Department of Physical Medicine & Rehabilitation, University of California, 
      Davis, CA, USA.
FAU - Abresch, Richard
AU  - Abresch R
FAU - Han, Jay J
AU  - Han JJ
FAU - Nicorici, Alina
AU  - Nicorici A
FAU - Goude Keller, Erica
AU  - Goude Keller E
FAU - Elfring, Gary
AU  - Elfring G
FAU - Reha, Allen
AU  - Reha A
FAU - Barth, Jay
AU  - Barth J
FAU - McDonald, Craig M
AU  - McDonald CM
LA  - eng
PT  - Journal Article
DEP - 20120125
PL  - United States
TA  - PLoS Curr
JT  - PLoS currents
JID - 101515638
PMC - PMC3269886
EDAT- 2012/02/07 06:00
MHDA- 2012/02/07 06:01
PMCR- 2012/03/13
CRDT- 2012/03/30 06:00
PHST- 2012/01/26 00:00 [accepted]
PHST- 2012/03/30 06:00 [entrez]
PHST- 2012/02/07 06:00 [pubmed]
PHST- 2012/02/07 06:01 [medline]
PHST- 2012/03/13 00:00 [pmc-release]
AID - k/-/-/3vct9230jm3zg/1 [pii]
AID - http://knol.google.com/k/-/-/3vct9230jm3zg/1 [pii]
AID - 10.1371/currents.RRN1297 [doi]
PST - epublish
SO  - PLoS Curr. 2012 Jan 25;4:RRN1297. doi: 10.1371/currents.RRN1297.