PMID- 22308070
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1229-1552 (Print)
IS  - 1229-1552 (Linking)
VI  - 1
IP  - 1
DP  - 2009 Jul
TI  - Helicobacter pylori Infection and Inflammation: Implication for the 
      Pathophysiology of Diabetes and Coronary Heart Disease in Asian Indians.
PG  - 45-50
AB  - Asian Indians living in the Indian subcontinent or abroad experience high rate of 
      coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). Asian Indians 
      are also known to suffer from various infections, particularly during their 
      childhood. One such chronic infection is with Helicobacter pylori (H. pylori). 
      Since H. pylori with its specific virulence factor cytotoxin-associated gene A 
      (cagA) has been suggested to be associated with CHD, a role of this H. pylori 
      infection was investigated in the pathogenesis of CHD in Asian Indians living in 
      Bangladesh. H. pylori (CagA) infected subjects with CHD (HP+ve cases, n=21), and 
      without CHD (HP+ve controls, n=20), and non-infected without CHD (HP-ve normal 
      controls, n=21) were included in this study. Thromboxane (TXB), an index of 
      platelet activation, was found to be significantly higher in the HP+ve cases 
      (p=0.05), but not in the HP+ve controls (p=0.88) when compared with HP-ve 
      controls. Analyses of lipid profiles revealed that while triglycerides, total 
      cholesterol and LDL did not show any significant changes, HDL was significantly 
      lower in both the HP+ve cases (p=0.0003) and controls (p=0.005). The mean fasting 
      glucose level in the HP+ve cases was markedly increased (p>0.0001), while it was 
      intermediate in the HP+ve controls, and lowest in the HP-ve controls. HOMA-IR 
      values, a measure of insulin resistance, did not reflect any substantial 
      differences between the HP+ve and HP-ve controls, but they were highly 
      significantly different between the HP+ve cases and HP-ve controls. HOMA-B, 
      indicating insulin secretory dysfunction (ISD), was significantly higher in both 
      the HP+ve groups when compared with the normal controls. The data indicate that 
      H. pylori infection is associated with impaired insulin secretion, and that a 
      component of insulin resistance that occurs independent of H. pylori can then 
      lead to a worsening of glucose tolerance and the development of CHD. This is the 
      first demonstration to our knowledge that H. pylori (CagA) infection is 
      associated with insulin secretory dysfunction in human subjects. Since many Asian 
      Indians contract various other chronic and acute infections, it is important to 
      investigate the role of H. pylori and other infectious agents in the pathogenesis 
      of T2DM and CHD.
FAU - Rahman, M Afzalur
AU  - Rahman MA
AD  - National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh.
FAU - Cope, Mark B
AU  - Cope MB
FAU - Sarker, Shafique A
AU  - Sarker SA
FAU - Garvey, W Timothy
AU  - Garvey WT
FAU - Chaudhury, Habib S
AU  - Chaudhury HS
FAU - Khaled, Mohammad A
AU  - Khaled MA
LA  - eng
GR  - P60 DK079626/DK/NIDDK NIH HHS/United States
GR  - P60 DK079626-01/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PL  - Korea (South)
TA  - J Life Sci
JT  - Journal of life science
JID - 101084577
PMC - PMC3269913
MID - NIHMS335594
EDAT- 2009/07/01 00:00
MHDA- 2009/07/01 00:01
PMCR- 2012/02/01
CRDT- 2012/02/07 06:00
PHST- 2012/02/07 06:00 [entrez]
PHST- 2009/07/01 00:00 [pubmed]
PHST- 2009/07/01 00:01 [medline]
PHST- 2012/02/01 00:00 [pmc-release]
AID - 10.1080/09751270.2009.11885133 [doi]
PST - ppublish
SO  - J Life Sci. 2009 Jul;1(1):45-50. doi: 10.1080/09751270.2009.11885133.