PMID- 22309452
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 14
IP  - 1
DP  - 2012 Feb 6
TI  - Cardiovascular magnetic resonance by non contrast T1-mapping allows assessment of 
      severity of injury in acute myocardial infarction.
PG  - 15
LID - 10.1186/1532-429X-14-15 [doi]
AB  - BACKGROUND: Current cardiovascular magnetic resonance (CMR) methods, such as late 
      gadolinium enhancement (LGE) and oedema imaging (T2W) used to depict myocardial 
      ischemia, have limitations. Novel quantitative T1-mapping techniques have the 
      potential to further characterize the components of ischemic injury. In patients 
      with myocardial infarction (MI) we sought to investigate whether state-of the art 
      pre-contrast T1-mapping (1) detects acute myocardial injury, (2) allows for 
      quantification of the severity of damage when compared to standard techniques 
      such as LGE and T2W, and (3) has the ability to predict long term functional 
      recovery. METHODS: 3T CMR including T2W, T1-mapping and LGE was performed in 41 
      patients [of these, 78% were ST elevation MI (STEMI)] with acute MI at 12-48 hour 
      after chest pain onset and at 6 months (6M). Patients with STEMI underwent 
      primary PCI prior to CMR. Assessment of acute regional wall motion abnormalities, 
      acute segmental damaged fraction by T2W and LGE and mean segmental T1 values was 
      performed on matching short axis slices. LGE and improvement in regional wall 
      motion at 6M were also obtained. RESULTS: We found that the variability of T1 
      measurements was significantly lower compared to T2W and that, while the 
      diagnostic performance of acute T1-mapping for detecting myocardial injury was at 
      least as good as that of T2W-CMR in STEMI patients, it was superior to T2W 
      imaging in NSTEMI. There was a significant relationship between the segmental 
      damaged fraction assessed by either by LGE or T2W, and mean segmental T1 values 
      (P < 0.01). The index of salvaged myocardium derived by acute T1-mapping and 6M 
      LGE was not different to the one derived from T2W (P = 0.88). Furthermore, the 
      likelihood of improvement of segmental function at 6M decreased progressively as 
      acute T1 values increased (P < 0.0004). CONCLUSIONS: In acute MI, pre-contrast 
      T1-mapping allows assessment of the extent of myocardial damage. T1-mapping might 
      become an important complementary technique to LGE and T2W for identification of 
      reversible myocardial injury and prediction of functional recovery in acute MI.
FAU - Dall'Armellina, Erica
AU  - Dall'Armellina E
AD  - Oxford Centre for Clinical Magnetic Resonance Research, Department of 
      Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, 
      UK. stefan.neubauer@cardiov.ox.ac.uk
FAU - Piechnik, Stefan K
AU  - Piechnik SK
FAU - Ferreira, Vanessa M
AU  - Ferreira VM
FAU - Si, Quang Le
AU  - Si QL
FAU - Robson, Matthew D
AU  - Robson MD
FAU - Francis, Jane M
AU  - Francis JM
FAU - Cuculi, Florim
AU  - Cuculi F
FAU - Kharbanda, Rajesh K
AU  - Kharbanda RK
FAU - Banning, Adrian P
AU  - Banning AP
FAU - Choudhury, Robin P
AU  - Choudhury RP
FAU - Karamitsos, Theodoros D
AU  - Karamitsos TD
FAU - Neubauer, Stefan
AU  - Neubauer S
LA  - eng
GR  - G0701128/MRC_/Medical Research Council/United Kingdom
GR  - 088291/WT_/Wellcome Trust/United Kingdom
GR  - 090532/WT_/Wellcome Trust/United Kingdom
GR  - G0900883/MRC_/Medical Research Council/United Kingdom
GR  - G0700796/MRC_/Medical Research Council/United Kingdom
GR  - BHF_/British Heart Foundation/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120206
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - 84F6U3J2R6 (gadodiamide)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Analysis of Variance
MH  - Angioplasty, Balloon, Coronary
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - Edema, Cardiac/diagnosis/pathology
MH  - England
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - Logistic Models
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis/pathology/physiopathology/*therapy
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - ROC Curve
MH  - Recovery of Function
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC3312869
EDAT- 2012/02/09 06:00
MHDA- 2012/06/05 06:00
PMCR- 2012/02/06
CRDT- 2012/02/08 06:00
PHST- 2011/11/10 00:00 [received]
PHST- 2012/02/06 00:00 [accepted]
PHST- 2012/02/08 06:00 [entrez]
PHST- 2012/02/09 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
PHST- 2012/02/06 00:00 [pmc-release]
AID - S1097-6647(23)00642-7 [pii]
AID - 1532-429X-14-15 [pii]
AID - 10.1186/1532-429X-14-15 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2012 Feb 6;14(1):15. doi: 10.1186/1532-429X-14-15.