PMID- 22309845
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20211021
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 14
IP  - 1
DP  - 2012 Feb 6
TI  - Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in 
      Turkey.
PG  - R27
LID - 10.1186/ar3730 [doi]
AB  - INTRODUCTION: HLA-B*51 and HLA-B*52 are two close human leukocyte antigen (HLA) 
      allele groups with minor amino acid differences. However, they are associated 
      with two different vasculitides (HLA-B*51 in Behcet's disease and HLA-B*52 in 
      Takayasu's arteritis (TAK)) and with major clinical and immunological 
      differences. In this study, we aimed to screen a large cohort of TAK patients 
      from Turkey for the presence of HLA-B*51 and HLA-B*52 as susceptibility and 
      severity factors. METHODS: TAK patients (n = 330) followed at a total of 15 
      centers were included in the study. The mean age of the patients was 37.8 years, 
      and 86% were women. DNA samples from the patients and healthy controls (HC; n = 
      210) were isolated, and the presence of HLA-B*51 or HLA-B*52 was screened for by 
      using PCR with sequence-specific primers. RESULTS: We found a significant 
      association of HLA-B*52 with TAK (20.9% vs HC = 6.7%, P = 0.000, OR = 3.7, 95% CI 
      = 2.02 to 6.77). The distribution of HLA-B*51 did not differ between TAK patients 
      and HCs (22.7% vs 24.8%, OR = 0.9, 95% CI = 0.60 to 1.34). The presence of 
      HLA-B*52 decreased in late-onset patients (> 40 years of age; 12.0%, P = 0.024, 
      OR = 0.43, 95% CI = 0.20 to 0.91). Patients with angiographic type I disease with 
      limited aortic involvement also had a lower presence of HLA-B*52 compared to 
      those with all other disease subtypes (13.1% vs 26%, P = 0.005, OR = 0.43, 95% CI 
      = 0.23 to 0.78). CONCLUSIONS: In this study, the previously reported association 
      of TAK with HLA-B*52 in other populations was confirmed in patients from Turkey. 
      The functional relevance of HLA-B*52 in TAK pathogenesis needs to be explored 
      further.
FAU - Sahin, Ziver
AU  - Sahin Z
AD  - Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Capa 
      34093, Istanbul, Turkey.
FAU - Bicakcigil, Muge
AU  - Bicakcigil M
FAU - Aksu, Kenan
AU  - Aksu K
FAU - Kamali, Sevil
AU  - Kamali S
FAU - Akar, Servet
AU  - Akar S
FAU - Onen, Fatos
AU  - Onen F
FAU - Karadag, Omer
AU  - Karadag O
FAU - Ozbalkan, Zeynep
AU  - Ozbalkan Z
FAU - Ates, Askin
AU  - Ates A
FAU - Ozer, Huseyin Te
AU  - Ozer HT
FAU - Yilmaz, Vuslat
AU  - Yilmaz V
FAU - Seyahi, Emire
AU  - Seyahi E
FAU - Ozturk, Mehmet A
AU  - Ozturk MA
FAU - Cefle, Ayse
AU  - Cefle A
FAU - Cobankara, Veli
AU  - Cobankara V
FAU - Onat, A Mesut
AU  - Onat AM
FAU - Tunc, Ercan
AU  - Tunc E
FAU - Duzgun, Nursen
AU  - Duzgun N
FAU - Aydin, Sibel Z
AU  - Aydin SZ
FAU - Yilmaz, Neslihan
AU  - Yilmaz N
FAU - Fresko, Izzet
AU  - Fresko I
FAU - Karaaslan, Yasar
AU  - Karaaslan Y
FAU - Kiraz, Sedat
AU  - Kiraz S
FAU - Akkoc, Nurullah
AU  - Akkoc N
FAU - Inanc, Murat
AU  - Inanc M
FAU - Keser, Gokhan
AU  - Keser G
FAU - Uyar, F Aytul
AU  - Uyar FA
FAU - Direskeneli, Haner
AU  - Direskeneli H
FAU - Saruhan-Direskeneli, Guher
AU  - Saruhan-Direskeneli G
CN  - Turkish Takayasu Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120206
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
RN  - 0 (HLA-B51 Antigen)
RN  - 0 (HLA-B52 Antigen)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - HLA-B51 Antigen/*genetics
MH  - HLA-B52 Antigen/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Takayasu Arteritis/*genetics
MH  - Turkey
PMC - PMC3392822
EDAT- 2012/02/09 06:00
MHDA- 2012/12/18 06:00
PMCR- 2012/02/06
CRDT- 2012/02/08 06:00
PHST- 2011/09/17 00:00 [received]
PHST- 2012/01/12 00:00 [revised]
PHST- 2012/02/06 00:00 [accepted]
PHST- 2012/02/08 06:00 [entrez]
PHST- 2012/02/09 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
PHST- 2012/02/06 00:00 [pmc-release]
AID - ar3730 [pii]
AID - 10.1186/ar3730 [doi]
PST - epublish
SO  - Arthritis Res Ther. 2012 Feb 6;14(1):R27. doi: 10.1186/ar3730.