PMID- 22311497
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20120207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 29
IP  - 1
DP  - 2012 Feb
TI  - [Association of 1233A/G polymorphism of angiopoietin-2 gene with type 2 diabetes 
      mellitus and diabetic nephropathy].
PG  - 72-6
LID - 10.3760/cma.j.issn.1003-9406.2012.01.018 [doi]
AB  - OBJECTIVE: To investigate the association between single nucleotide polymorphisms 
      (SNP) of angiopoietin-2 (Ang-2) gene and type 2 diabetes mellitus (T2DM) and 
      diabetic nephropathy (DN). METHODS: Genotype and allele frequency of Ang-2 were 
      detected by amplification refractory mutation system-PCR(ARMS-PCR) in 221 cases 
      with T2DM and 104 normal controls. Monocyte chemoattractant protein-1(MCP-1) was 
      measured by ELISA. DN patients were divided into three groups according to 
      urinary albumin excretion rates (UAER), i.e. DN0: UAER < 30 mg/24 h, DN1: UAER 
      30-300 mg/24 h and DN2: UAER > 300 mg/24 h. RESULTS: Statistics showed: (1) 
      Genotype frequencies and allele frequencies in Ang-2 1233A/G had significant 
      difference but not Ang-2 759T/G and 1078A/G; (2) Comparing with those with 
      genotype AA, the relative risk of genotype (AG+ GG) suffered from T2DM and DN 
      were 2.265 fold (OR= 2.265, 95% CI: 1.223-1.402, P= 0.031), 1.789 fold (OR= 
      1.789, 95% CI: 0.889-1.021, P= 0.012), respectively; (3) The onset of DN was 
      related to Ang-2 1233A/G allele G (r= 1.321, OR= 1.427, 95% CI: 2.324-4.177, P= 
      0.034). CONCLUSION: Ang-2 1233A/G polymorphism may be associated with T2DM and 
      involved in onset and development of DN.
FAU - He, Quan
AU  - He Q
AD  - Department of Emergency, the First People's Hospital of Yunnan Province, Kunming, 
      Yunnan 650032, P. R. China. hequan2009@yeah.net.
FAU - Luo, Hai-ming
AU  - Luo HM
FAU - Zhu, Bao-sheng
AU  - Zhu BS
FAU - Tang, Xin-hua
AU  - Tang XH
FAU - Jiang, Lu-zhi
AU  - Jiang LZ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (Angiopoietin-2)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Angiopoietin-2/*genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Diabetic Nephropathies/*genetics
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Polymorphism, Single Nucleotide
EDAT- 2012/02/09 06:00
MHDA- 2012/07/11 06:00
CRDT- 2012/02/08 06:00
PHST- 2012/02/08 06:00 [entrez]
PHST- 2012/02/09 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
AID - 940629018 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2012.01.018 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012 Feb;29(1):72-6. doi: 
      10.3760/cma.j.issn.1003-9406.2012.01.018.