PMID- 22311714
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20211021
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 101
IP  - 7
DP  - 2012 Jul
TI  - Clues to detect tumor necrosis factor receptor-associated periodic syndrome 
      (TRAPS) among patients with idiopathic recurrent acute pericarditis: results of a 
      multicentre study.
PG  - 525-31
LID - 10.1007/s00392-012-0422-8 [doi]
AB  - BACKGROUND: The potential clinical expression of tumor necrosis factor 
      receptor-associated periodic syndrome (TRAPS), in the form of idiopathic 
      recurrent acute pericarditis (IRAP) has not been explored in the medical 
      literature. The aim of this study was to evaluate the incidence of TRAPS 
      mutations in patients with recurrent pericarditis and identify possible clues to 
      TRAPS diagnosis. METHODS: Therefore, 131 consecutive Caucasian IRAP patients were 
      investigated for mutations of the TRAPS gene and prospectively evaluated. 
      RESULTS: Out of 131 patients, 8 (6.1%) carried a mutation in the TNFRSF1A gene. 
      Compared with those without genetic mutations, patients with TRAPS mutations had 
      more frequently a positive family history for pericarditis and periodic fever 
      syndromes (p < 0.001), a higher mean number of recurrences after the first year 
      (p < 0.001), on colchicine treatment (p < 0.001), and a higher need of 
      immunosuppressive therapies (p < 0.001). CONCLUSION: TRAPS is a cause of 
      recurrent pericarditis in 6% of unselected cases with recurrent pericarditis. A 
      positive family history for pericarditis or periodic fever syndromes, a poor 
      response to colchicine, recurrences after the first year from the index attack or 
      on colchicine treatment, as well as the need of immunosuppressive agents are 
      clues of the possible presence of TNFRSF1A gene mutations in patients with 
      recurrent pericarditis.
FAU - Cantarini, Luca
AU  - Cantarini L
AD  - Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory 
      Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Italy. 
      cantariniluca@hotmail.com
FAU - Lucherini, Orso Maria
AU  - Lucherini OM
FAU - Brucato, Antonio
AU  - Brucato A
FAU - Barone, Luca
AU  - Barone L
FAU - Cumetti, Davide
AU  - Cumetti D
FAU - Iacoponi, Francesca
AU  - Iacoponi F
FAU - Rigante, Donato
AU  - Rigante D
FAU - Brambilla, Giovanni
AU  - Brambilla G
FAU - Penco, Silvana
AU  - Penco S
FAU - Brizi, Maria Giuseppina
AU  - Brizi MG
FAU - Patrosso, Maria Cristina
AU  - Patrosso MC
FAU - Valesini, Guido
AU  - Valesini G
FAU - Frediani, Bruno
AU  - Frediani B
FAU - Galeazzi, Mauro
AU  - Galeazzi M
FAU - Cimaz, Rolando
AU  - Cimaz R
FAU - Paolazzi, Giuseppe
AU  - Paolazzi G
FAU - Vitale, Antonio
AU  - Vitale A
FAU - Imazio, Massimo
AU  - Imazio M
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20120205
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (TNFRSF1A protein, human)
RN  - SML2Y3J35T (Colchicine)
RN  - Periodic fever, familial, autosomal dominant
SB  - IM
MH  - Acute Disease
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Adult
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Colchicine/therapeutic use
MH  - DNA Mutational Analysis
MH  - Female
MH  - Fever
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Hereditary Autoinflammatory Diseases/complications/*diagnosis/drug 
      therapy/genetics/immunology
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - *Mutation
MH  - Odds Ratio
MH  - Pedigree
MH  - Pericarditis/drug therapy/*genetics/immunology
MH  - Phenotype
MH  - Prospective Studies
MH  - Receptors, Tumor Necrosis Factor, Type I/*genetics
MH  - Recurrence
MH  - Risk Assessment
MH  - Risk Factors
EDAT- 2012/02/09 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/02/08 06:00
PHST- 2011/07/30 00:00 [received]
PHST- 2012/01/26 00:00 [accepted]
PHST- 2012/02/08 06:00 [entrez]
PHST- 2012/02/09 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - 10.1007/s00392-012-0422-8 [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2012 Jul;101(7):525-31. doi: 10.1007/s00392-012-0422-8. Epub 
      2012 Feb 5.