PMID- 22315585
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20220318
IS  - 1687-4765 (Electronic)
IS  - 1687-4757 (Print)
VI  - 2012
DP  - 2012
TI  - PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation 
      Pathways.
PG  - 616371
LID - 10.1155/2012/616371 [doi]
LID - 616371
AB  - The paraoxonase (PON) group of enzymes, composed of PON1, PON2, and PON3, play an 
      important role in decreasing oxidative stress by degrading lipid peroxides. PON1 
      synthesis is upregulated by PPAR. Several pharmacological compounds (acting as 
      antioxidants and, hence, atheroprotective) stimulate both PPAR activity and PON1 
      expression. Recent evidence suggests that PON1 and the monocyte chemoattractant 
      protein-1 (MCP-1) are involved in coordinating the inflammatory response in 
      damaged tissues; PPAR may be central in the regulation of these biochemical 
      pathways. This article reviews the state of knowledge on PON1 biochemistry and 
      function, the influence of genetic variation, and the regulation of PON1 
      expression by pharmaceutical compounds that increase PPAR activity. We also 
      describe recent lines of evidence suggesting links between PON1 and MCP-1 and how 
      their production may be regulated by PPAR.
FAU - Camps, Jordi
AU  - Camps J
AD  - Centre de Recerca Biomedica, Hospital Universitari de Sant Joan, Institut 
      d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, 
      Spain.
FAU - Garcia-Heredia, Anabel
AU  - Garcia-Heredia A
FAU - Rull, Anna
AU  - Rull A
FAU - Alonso-Villaverde, Carlos
AU  - Alonso-Villaverde C
FAU - Aragones, Gerard
AU  - Aragones G
FAU - Beltran-Debon, Raul
AU  - Beltran-Debon R
FAU - Rodriguez-Gallego, Esther
AU  - Rodriguez-Gallego E
FAU - Joven, Jorge
AU  - Joven J
LA  - eng
PT  - Journal Article
DEP - 20120124
PL  - United States
TA  - PPAR Res
JT  - PPAR research
JID - 101269101
PMC - PMC3270466
EDAT- 2012/02/09 06:00
MHDA- 2012/02/09 06:01
PMCR- 2012/01/24
CRDT- 2012/02/09 06:00
PHST- 2011/07/26 00:00 [received]
PHST- 2011/10/17 00:00 [accepted]
PHST- 2012/02/09 06:00 [entrez]
PHST- 2012/02/09 06:00 [pubmed]
PHST- 2012/02/09 06:01 [medline]
PHST- 2012/01/24 00:00 [pmc-release]
AID - 10.1155/2012/616371 [doi]
PST - ppublish
SO  - PPAR Res. 2012;2012:616371. doi: 10.1155/2012/616371. Epub 2012 Jan 24.