PMID- 22315953
OWN - NLM
STAT- MEDLINE
DCOM- 20140702
LR  - 20120209
IS  - 1556-7125 (Electronic)
IS  - 1535-3141 (Linking)
VI  - 9
IP  - 2
DP  - 2012 Feb
TI  - Acute allergic reactions in Vietnamese children after drinking a new milk 
      product.
PG  - 156-9
LID - 10.1089/fpd.2011.1059 [doi]
AB  - In early October 2009, pediatricians in hospitals in Ho Chi Minh City (HCMC) 
      reported an unusual increase in the number of children presenting with an acute 
      onset of itchy rash and some with breathing difficulties shortly after drinking 
      milk products. The pediatricians considered the illness to be an allergic 
      reaction to milk. The objective of our investigation was to identify the cause of 
      this acute illness. Following early case reports, all hospitals in HCMC were 
      requested to report cases of this illness. Parents were advised to take children 
      with symptoms to a hospital immediately. A case-series was conducted to generate 
      hypotheses on the possible causes of the illness and was followed by a 
      case-control study to test the hypothesis. Parents of all cases and controls were 
      interviewed face-to-face. The association between food items and the allergy was 
      tested using conditional logistics regression. From 9 to 28 October 2009, 19 
      cases fulfilled the case definition, and 16 of the 17 cases included in the study 
      had consumed milk supplemented with galacto-oligosaccharides (GOS) shortly before 
      the onset of illness. Fifty age-matched, neighborhood controls were enrolled into 
      the case control study. Of the 30 food items consumed by study participants in 
      the preceding 24 h, only the odds ratio (OR) of milk supplemented with GOS was 
      statistically significant: OR=34.0 (95% CI=3.9, 294.8). Laboratory tests of this 
      milk product did not reveal any unusual properties, chemicals, or other toxic 
      substances. This is the first report of an acute allergic reaction to fresh milk 
      supplemented with GOS. However, the specific allergen in this product was not 
      identified. Further cases were not reported once this product was withdrawn from 
      sale. Vietnam's food safety authorities should expand laboratory capacity to 
      detect allergens in food products.
FAU - Vo, Thuan Huu
AU  - Vo TH
AD  - Institute of Hygiene and Public Health, Ho Chi Minh City, Vietnam. 
      vo.huuthuan@yahoo.com
FAU - Le, Ninh Hoang
AU  - Le NH
FAU - Patel, Mahomed Said
AU  - Patel MS
FAU - Phan, Lan Trong
AU  - Phan LT
FAU - Tran Minh, Nhu Nguyen
AU  - Tran Minh NN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Foodborne Pathog Dis
JT  - Foodborne pathogens and disease
JID - 101120121
RN  - 0 (Allergens)
RN  - 0 (Oligosaccharides)
SB  - IM
MH  - Adolescent
MH  - Allergens/*adverse effects
MH  - Animals
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Dietary Supplements/*adverse effects
MH  - Female
MH  - Food Hypersensitivity/diagnosis/*epidemiology/etiology
MH  - Food Safety
MH  - Humans
MH  - Infant
MH  - Male
MH  - Milk/*adverse effects
MH  - Oligosaccharides/*adverse effects
MH  - Vietnam/epidemiology
EDAT- 2012/02/10 06:00
MHDA- 2014/07/06 06:00
CRDT- 2012/02/10 06:00
PHST- 2012/02/10 06:00 [entrez]
PHST- 2012/02/10 06:00 [pubmed]
PHST- 2014/07/06 06:00 [medline]
AID - 10.1089/fpd.2011.1059 [doi]
PST - ppublish
SO  - Foodborne Pathog Dis. 2012 Feb;9(2):156-9. doi: 10.1089/fpd.2011.1059.