PMID- 22318200
OWN - NLM
STAT- MEDLINE
DCOM- 20120507
LR  - 20211021
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 119
IP  - 12
DP  - 2012 Mar 22
TI  - Quantitative differences in HTLV-I antibody responses: classification and 
      relative risk assessment for asymptomatic carriers and ATL and HAM/TSP patients 
      from Jamaica.
PG  - 2829-36
LID - 10.1182/blood-2011-11-390807 [doi]
AB  - Adult T-cell leukemia (ATL) and human T-cell lymphotropic virus type I 
      (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are known 
      to be caused by HTLV-I infection. However, current methods used to determine 
      HTLV-I infection do not differentiate between HTLV-I asymptomatic carriers (ACs) 
      and ATL and HAM/TSP patients. Using the luciferase immunoprecipitation system, a 
      highly sensitive, quantitative technology that can efficiently detect HTLV-I Ab 
      responses, we examined Ab responses for HTLV-I in serum/plasma samples from 439 
      subjects in Jamaica, including HTLV-I-seronegative donors, ACs, and ATL and 
      HAM/TSP patients. The Ab responses of HTLV-I-infected subjects differed 
      significantly from those of seronegative donors for all 3 immunodominant 
      proteins, Gag, Env, and Tax. HAM/TSP patients had significantly higher Ab 
      responses for Gag and Env compared with ACs, and Ab responses for all 3 Ags were 
      higher in HAM/TSP patients than in ATL patients. Moreover, immunoreactivities for 
      HTLV-I Ags as determined by the luciferase immunoprecipitation system could 
      distinguish HAM/TSP patients from ACs at a true-positive rate of 85.42% and from 
      ATL patients at a true-positive rate of 75.00%, and modeled in conjunction with 
      subject information to distinguish HAM/TSP patients from ACs (odds ratio = 14.12) 
      and from ATL patients (odds ratio = 7.00). The relative risk assessment resulting 
      from these significant differences between Ab responses in HTLV-I-infected groups 
      may be a useful diagnostic tool in the future.
FAU - Enose-Akahata, Yoshimi
AU  - Enose-Akahata Y
AD  - Viral Immunology Section, Neuroimmunology Branch, Division of Intramural 
      Research, National Institute of Neurological Disorders and Stroke, National 
      Institutes of Health, Bethesda, MD 20892, USA.
FAU - Abrams, Anna
AU  - Abrams A
FAU - Johnson, Kory R
AU  - Johnson KR
FAU - Maloney, Elizabeth M
AU  - Maloney EM
FAU - Jacobson, Steven
AU  - Jacobson S
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20120207
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antibodies, Viral/*blood
MH  - Antigens, Viral/immunology
MH  - Biomarkers/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HTLV-I Infections/*blood/immunology
MH  - Human T-lymphotropic virus 1/immunology
MH  - Humans
MH  - Immunoprecipitation
MH  - Jamaica
MH  - Leukemia-Lymphoma, Adult T-Cell/*blood/immunology
MH  - Male
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/*blood/immunology
MH  - Risk Factors
MH  - Young Adult
PMC - PMC3327461
EDAT- 2012/02/10 06:00
MHDA- 2012/05/09 06:00
PMCR- 2013/03/22
CRDT- 2012/02/10 06:00
PHST- 2012/02/10 06:00 [entrez]
PHST- 2012/02/10 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
PHST- 2013/03/22 00:00 [pmc-release]
AID - S0006-4971(20)49215-8 [pii]
AID - 2011/390807 [pii]
AID - 10.1182/blood-2011-11-390807 [doi]
PST - ppublish
SO  - Blood. 2012 Mar 22;119(12):2829-36. doi: 10.1182/blood-2011-11-390807. Epub 2012 
      Feb 7.