PMID- 22320703
OWN - NLM
STAT- MEDLINE
DCOM- 20140429
LR  - 20181203
IS  - 1472-8206 (Electronic)
IS  - 0767-3981 (Linking)
VI  - 27
IP  - 4
DP  - 2013 Aug
TI  - Beneficial effects of beta-blockers on left ventricular function and cellular 
      energy reserve in patients with heart failure.
PG  - 455-64
LID - 10.1111/j.1472-8206.2012.01029.x [doi]
AB  - Beta-blockers have been shown to improve left ventricular (LV) function in 
      patients with heart failure. The aim of this study is to non-invasively assess, 
      by means of in vivo 31P-magnetic resonance spectroscopy (31P-MRS), the effects of 
      beta-blockers on LV cardiac phosphocreatine and adenosine triphosphate (PCr/ATP) 
      ratio in patients with heart failure. Ten heart failure patients on full medical 
      therapy were beta-blocked by either carvedilol or bisoprolol. Before and after 3 
      months of treatment, exercise testing, 2D echocardiography, MRS, New York Heart 
      Association (NYHA) class, ejection fraction (EF), maximal rate-pressure product 
      and exercise metabolic equivalent system (METS) were evaluated. Relative 
      concentrations of PCr and ATP were determined by cardiac 31P-MRS. After 
      beta-blockade, NYHA class decreased (from 2.2 +/- 0.54 to 1.9 +/- 0.52, P = 0.05), 
      whereas EF (from 33 +/- 7 to 44 +/- 6%, P = 0.0009) and METS (from 6.74 +/- 2.12 to 
      8.03 +/- 2.39, P = 0.01) increased. Accordingly, the mean cardiac PCr/ATP ratio 
      increased by 33% (from 1.48 +/- 0.22 to 1.81 +/- 0.48, P = 0.03). 
      Beta-blockade-induced symptomatic and functional improvement in patients with 
      heart failure is associated to increased PCr/ATP ratio, indicating preservation 
      of myocardial high-energy phosphate levels.
CI  - (c) 2012 The Authors Fundamental and Clinical Pharmacology (c) 2012 Societe Francaise 
      de Pharmacologie et de Therapeutique. Published by John Wiley & Sons Ltd.
FAU - Spoladore, Roberto
AU  - Spoladore R
AD  - Clinical Cardiology - Heart Failure Clinic, Istituto Scientifico-Universita 
      Vita/Salute San Raffaele, Via Olgettina 60, 20132 Milano, Italy. 
      spoladore.roberto@hsr.it
FAU - Fragasso, Gabriele
AU  - Fragasso G
FAU - Perseghin, Gianluca
AU  - Perseghin G
FAU - De Cobelli, Francesco
AU  - De Cobelli F
FAU - Esposito, Antonio
AU  - Esposito A
FAU - Maranta, Francesco
AU  - Maranta F
FAU - Calori, Giliola
AU  - Calori G
FAU - Locatelli, Massimo
AU  - Locatelli M
FAU - Lattuada, Guido
AU  - Lattuada G
FAU - Scifo, Paola
AU  - Scifo P
FAU - Del Maschio, Alessandro
AU  - Del Maschio A
FAU - Margonato, Alberto
AU  - Margonato A
LA  - eng
PT  - Journal Article
DEP - 20120209
PL  - England
TA  - Fundam Clin Pharmacol
JT  - Fundamental & clinical pharmacology
JID - 8710411
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Carbazoles)
RN  - 0 (Propanolamines)
RN  - 0K47UL67F2 (Carvedilol)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - Y41JS2NL6U (Bisoprolol)
SB  - IM
MH  - Adenosine Triphosphate/metabolism
MH  - Adrenergic beta-Antagonists/*therapeutic use
MH  - Aged
MH  - Bisoprolol/therapeutic use
MH  - Carbazoles/therapeutic use
MH  - Carvedilol
MH  - Echocardiography/methods
MH  - Energy Metabolism
MH  - Female
MH  - Heart/*drug effects
MH  - Heart Failure/*drug therapy/metabolism/physiopathology
MH  - Humans
MH  - Magnetic Resonance Spectroscopy/methods
MH  - Male
MH  - Propanolamines/therapeutic use
MH  - Ventricular Function, Left/*drug effects
EDAT- 2012/02/11 06:00
MHDA- 2014/04/30 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2014/04/30 06:00 [medline]
AID - 10.1111/j.1472-8206.2012.01029.x [doi]
PST - ppublish
SO  - Fundam Clin Pharmacol. 2013 Aug;27(4):455-64. doi: 
      10.1111/j.1472-8206.2012.01029.x. Epub 2012 Feb 9.