PMID- 22320985
OWN - NLM
STAT- MEDLINE
DCOM- 20120628
LR  - 20210103
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 12
IP  - 10
DP  - 2011
TI  - Loss of heterozygosity at 6p21 and HLA class I expression in esophageal squamous 
      cell carcinomas in China.
PG  - 2741-5
AB  - BACKGROUND AND OBJECTIVE: The loss or downregulation of human leukocyte antigen ( 
      HLA-I) has been proposed to contribute to immune evasion by cancer cells. Since 
      the human leukocyte antigen (HLA-I) complex is located at 6p21.3, loss of 
      heterozygosity of this region may alter HLA class I tumor phenotypes. The aim of 
      this study was to analysis loss of heterozygosity (LOH) of chromosome 6p in ESCC 
      samples and correlate this with HLA class I expression. MATERIALS AND METHODS: A 
      total of 87 formalin-fixed, paraffin-embeded and frozen-fresh of ECSS lesions 
      were collected. HLA-Iand antigen-processing machinery component expression was 
      investigated by immunohistochemistry with anti-HLA class I monoclonal antibody 
      and a panel of 49 ESCCs with downregulated HLA class I expression were selected 
      for LOH studies using 3 microsatellite markers located at 6p21.3 
      (D6S105,D6S265,D6S273). RESULTS: HLA-Iantigen,TAP1 and LMP were lost or 
      down-regulated in 57.5, 29.8 and 47.0% of the ESCC lesions, respectively. In 
      23/49(46.9%) of the ESCCs, allelic loss for at least one locus at 6p21.3 was 
      found. CONCLUSIONS: Our data show that downregulation of HLA class I expression 
      is correlated with loss of heterozygosity regions at 6p21.3 in ESCC.
FAU - Zhao, Xiaogang
AU  - Zhao X
AD  - Thoracic Surgery, Second Hospital of Shandong University, Jinan, China.
FAU - Sun, Qifeng
AU  - Sun Q
FAU - Tian, Hui
AU  - Tian H
FAU - Cong, Bo
AU  - Cong B
FAU - Jiang, Xingtao
AU  - Jiang X
FAU - Peng, Chuanliang
AU  - Peng C
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - China
MH  - Chromosomes, Human, Pair 6/*genetics
MH  - Esophageal Neoplasms/*genetics/pathology
MH  - Female
MH  - Genes, MHC Class I/genetics
MH  - Histocompatibility Antigens Class I/*genetics/metabolism
MH  - Humans
MH  - *Loss of Heterozygosity
MH  - Male
MH  - Microsatellite Repeats
MH  - Middle Aged
MH  - Phenotype
MH  - Tumor Escape/genetics
EDAT- 2012/02/11 06:00
MHDA- 2012/06/29 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2012/06/29 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2011;12(10):2741-5.