PMID- 22321195
OWN - NLM
STAT- MEDLINE
DCOM- 20120803
LR  - 20220317
IS  - 1532-3102 (Electronic)
IS  - 0143-4004 (Linking)
VI  - 33
IP  - 5
DP  - 2012 May
TI  - Maternal resveratrol treatment during pregnancy improves adverse fetal outcomes 
      in a rat model of severe hypoxia.
PG  - 449-52
LID - 10.1016/j.placenta.2012.01.012 [doi]
AB  - Prenatal hypoxia is a common complication in pregnancy. We sought to determine 
      whether resveratrol, a phytoalexin shown to improve health in several species, 
      improves fetal outcomes associated with prenatal hypoxia in rats. Supplementation 
      of maternal diets with resveratrol (4 g/kg diet) from gestational day (GD) 7 to 
      GD21 almost completely reversed fetal demise in hypoxic (8.5% oxygen) 
      pregnancies. We also show that resveratrol crosses the placenta, and may affect 
      the fetus directly.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Bourque, S L
AU  - Bourque SL
AD  - Department of Obstetrics and Gynecology, University of Alberta, Edmonton, 
      Alberta, Canada.
FAU - Dolinsky, V W
AU  - Dolinsky VW
FAU - Dyck, J R B
AU  - Dyck JR
FAU - Davidge, S T
AU  - Davidge ST
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120210
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
RN  - 0 (Antioxidants)
RN  - 0 (Stilbenes)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Antioxidants/*therapeutic use
MH  - Drug Evaluation, Preclinical
MH  - Female
MH  - Fetal Hypoxia/*drug therapy
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Rats
MH  - Resveratrol
MH  - Stilbenes/*therapeutic use
EDAT- 2012/02/11 06:00
MHDA- 2012/08/04 06:00
CRDT- 2012/02/11 06:00
PHST- 2011/09/20 00:00 [received]
PHST- 2012/01/12 00:00 [revised]
PHST- 2012/01/13 00:00 [accepted]
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2012/08/04 06:00 [medline]
AID - S0143-4004(12)00038-0 [pii]
AID - 10.1016/j.placenta.2012.01.012 [doi]
PST - ppublish
SO  - Placenta. 2012 May;33(5):449-52. doi: 10.1016/j.placenta.2012.01.012. Epub 2012 
      Feb 10.