PMID- 22321275
OWN - NLM
STAT- MEDLINE
DCOM- 20150514
LR  - 20120210
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 39
IP  - 10
DP  - 2011 Oct
TI  - [Value of cardiac magnetic resonance imaging for the diagnosis of cardiac 
      amyloidosis].
PG  - 915-9
AB  - OBJECTIVE: To observe the clinical features and cardiac magnetic resonance 
      imaging (CMR) characteristics of patients with endomyocardial biopsy (EMB)-proven 
      cardiac amyloidosis (CA). METHODS: EMB proven CA patients underwent CMR 
      examination from September 2006 to December 2010 were included. The findings of 
      clinical manifestation, electrocardiogram, echocardiography and CMR were 
      analyzed. RESULTS: Among the 18 patients with EMB verified CA, 5 patients 
      underwent CMR. All 5 patients had heart failure symptoms and electrocardiogram 
      was abnormal. Echocardiogram showed concentric left ventricular hypertrophy, 
      granular appearance of the myocardium, left atrial enlargement and moderate to 
      severe left ventricular diastolic dysfunction. CMR revealed increased thickness 
      of the left ventricular wall (especially at the inter-ventricular septum), 
      enlarged bilateral auricle, restricted left ventricular filling with normal or 
      mild to moderate reduced systolic function. Pleural and pericardial effusions 
      were observed in 2 patients. Abnormal late gadolinium enhancement (LGE) was 
      detected in all 5 patients. CMR revealed different patterns of LGE. Left 
      ventricular global subendocardial delayed gadolinium enhancement or transmural 
      delayed gadolinium enhancement were found, and patients also showed line-, 
      granular- or patchy-like enhancement. The degree and range of LGE paralleled the 
      disease course and were consistent with electrocardiogram changes. CONCLUSIONS: 
      As a noninvasive diagnostic tool, CMR is valuable in the diagnosis of CA. For 
      patients with clinical suspicion of CA, CMR could be a helpful diagnostic tool, 
      especially in the hospitals where EMB is not available.
FAU - Zhu, Kong-bo
AU  - Zhu KB
AD  - Department of Cardiology, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
FAU - Cheng, Zhong-wei
AU  - Cheng ZW
FAU - Tian, Zhuang
AU  - Tian Z
FAU - Zhao, Da-chun
AU  - Zhao DC
FAU - Liu, Yong-tai
AU  - Liu YT
FAU - Lin, Xue
AU  - Lin X
FAU - Chen, Tai-bo
AU  - Chen TB
FAU - Xie, Hong-zhi
AU  - Xie HZ
FAU - Zeng, Yong
AU  - Zeng Y
FAU - Fang, Li-gang
AU  - Fang LG
FAU - Jiang, Xiu-chun
AU  - Jiang XC
FAU - Cui, Quan-cai
AU  - Cui QC
FAU - Fang, Quan
AU  - Fang Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
RN  - AU0V1LM3JT (Gadolinium)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Amyloidosis/*diagnosis
MH  - Biopsy
MH  - Cardiomyopathies/*diagnosis
MH  - Echocardiography
MH  - Electrocardiography
MH  - Gadolinium
MH  - Gadolinium DTPA
MH  - Humans
MH  - Hypertrophy, Left Ventricular
MH  - *Magnetic Resonance Imaging
MH  - Myocardium
MH  - Systole
EDAT- 2012/02/11 06:00
MHDA- 2015/05/15 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2011 Oct;39(10):915-9.