PMID- 22323450
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20220408
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 119
IP  - 15
DP  - 2012 Apr 12
TI  - Regulation of dendritic cell development by GM-CSF: molecular control and 
      implications for immune homeostasis and therapy.
PG  - 3383-93
LID - 10.1182/blood-2011-11-370130 [doi]
AB  - Dendritic cells (DCs) represent a small and heterogeneous fraction of the 
      hematopoietic system, specialized in antigen capture, processing, and 
      presentation. The different DC subsets act as sentinels throughout the body and 
      perform a key role in the induction of immunogenic as well as tolerogenic immune 
      responses. Because of their limited lifespan, continuous replenishment of DC is 
      required. Whereas the importance of GM-CSF in regulating DC homeostasis has long 
      been underestimated, this cytokine is currently considered a critical factor for 
      DC development under both steady-state and inflammatory conditions. Regulation of 
      cellular actions by GM-CSF depends on the activation of intracellular signaling 
      modules, including JAK/STAT, MAPK, PI3K, and canonical NF-kappaB. By directing the 
      activity of transcription factors and other cellular effector proteins, these 
      pathways influence differentiation, survival and/or proliferation of uncommitted 
      hematopoietic progenitors, and DC subset-specific precursors, thereby 
      contributing to specific aspects of DC subset development. The specific 
      intracellular events resulting from GM-CSF-induced signaling provide a molecular 
      explanation for GM-CSF-dependent subset distribution as well as clues to the 
      specific characteristics and functions of GM-CSF-differentiated DCs compared with 
      DCs generated by fms-related tyrosine kinase 3 ligand. This knowledge can be used 
      to identify therapeutic targets to improve GM-CSF-dependent DC-based strategies 
      to regulate immunity.
FAU - van de Laar, Lianne
AU  - van de Laar L
AD  - Department of Gastroenterology and Hepatology, Erasmus MC-University Medical 
      Center, Rotterdam, The Netherlands.
FAU - Coffer, Paul J
AU  - Coffer PJ
FAU - Woltman, Andrea M
AU  - Woltman AM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120208
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/drug effects/genetics
MH  - Dendritic Cells/*drug effects/metabolism/*physiology
MH  - Gene Expression Regulation/drug effects
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/*pharmacology/physiology
MH  - Homeostasis/drug effects/*immunology
MH  - Humans
MH  - Immunity, Cellular/*drug effects/genetics
MH  - Immunotherapy/*methods
MH  - Models, Biological
EDAT- 2012/02/11 06:00
MHDA- 2012/06/13 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - S0006-4971(20)49126-8 [pii]
AID - 10.1182/blood-2011-11-370130 [doi]
PST - ppublish
SO  - Blood. 2012 Apr 12;119(15):3383-93. doi: 10.1182/blood-2011-11-370130. Epub 2012 
      Feb 8.