PMID- 22323476
OWN - NLM
STAT- MEDLINE
DCOM- 20140409
LR  - 20130521
IS  - 1477-0393 (Electronic)
IS  - 0748-2337 (Linking)
VI  - 29
IP  - 5
DP  - 2013 Jun
TI  - The effects of exposure to electromagnetic field on rat myocardium.
PG  - 418-25
LID - 10.1177/0748233711434957 [doi]
AB  - Exposure to electromagnetic fields (EMFs) causes increased adverse effects on 
      biological systems. The aim of this study was to investigate the effects of EMF 
      on heart tissue by biochemical and histomorphological evaluations in EMF-exposed 
      adult rats. In this study, 28 male Wistar rats weighing 200-250 g were used. The 
      rats were divided into two groups: sham group (n = 14) and EMF group (n = 14). 
      Rats in sham group were exposed to same conditions as the EMF group except the 
      exposure to EMF. Rats in EMF group were exposed to a 50-Hz EMF of 3 mT for 
      4 h/day and 7 days/week for 2 months. After 2 months of exposure, rats were 
      killed; the hearts were excised and evaluated. Determination of oxidative stress 
      parameters was performed spectrophotometrically. To detect apoptotic cells, 
      terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) 
      staining and caspase-3 immunohistochemistry were performed. In EMF-exposed group, 
      levels of lipid peroxidation significantly increased and activities of superoxide 
      dismutase and glutathione peroxidase decreased compared with sham group. The 
      number of TUNEL-positive cells and caspase-3 immunoreactivity increased in 
      EMF-exposed rats compared with sham. Under electron microscopy, there were 
      mitochondrial degeneration, reduction in myofibrils, dilated sarcoplasmic 
      reticulum and perinuclear vacuolization in EMF-exposed rats. In conclusion, the 
      results show that the exposure to EMF causes oxidative stress, apoptosis and 
      morphologic damage in myocardium of adult rats. The results of our study indicate 
      that EMF-related changes in rat myocardium could be the result of increased 
      oxidative stress. Further studies are needed to demonstrate whether the exposure 
      to EMF can induce adverse effects on myocardium.
FAU - Kiray, Amac
AU  - Kiray A
AD  - Department of Anatomy, Dokuz Eylul University Medical School, Turkey.
FAU - Tayefi, Hamid
AU  - Tayefi H
FAU - Kiray, Muge
AU  - Kiray M
FAU - Bagriyanik, Husnu Alper
AU  - Bagriyanik HA
FAU - Pekcetin, Cetin
AU  - Pekcetin C
FAU - Ergur, Bekir Ugur
AU  - Ergur BU
FAU - Ozogul, Candan
AU  - Ozogul C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120209
PL  - England
TA  - Toxicol Ind Health
JT  - Toxicology and industrial health
JID - 8602702
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Apoptosis/radiation effects
MH  - Electromagnetic Fields/*adverse effects
MH  - Glutathione Peroxidase/metabolism
MH  - Heart/*radiation effects
MH  - Immunohistochemistry
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Myocardium/enzymology/metabolism/pathology
MH  - Oxidative Stress/radiation effects
MH  - Rats
MH  - Rats, Wistar
MH  - Statistics, Nonparametric
MH  - Superoxide Dismutase/metabolism
OTO - NOTNLM
OT  - Electromagnetic field
OT  - apoptosis
OT  - myocardium
OT  - oxidative stress
OT  - ultrastructure
EDAT- 2012/02/11 06:00
MHDA- 2014/04/10 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2014/04/10 06:00 [medline]
AID - 0748233711434957 [pii]
AID - 10.1177/0748233711434957 [doi]
PST - ppublish
SO  - Toxicol Ind Health. 2013 Jun;29(5):418-25. doi: 10.1177/0748233711434957. Epub 
      2012 Feb 9.