PMID- 22323870
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20211021
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 27
IP  - 2
DP  - 2012 Feb
TI  - A case of isolated light chain deposition disease in the duodenum.
PG  - 207-10
LID - 10.3346/jkms.2012.27.2.207 [doi]
AB  - Light chain deposition disease (LCDD) is a rare disorder associated with a clonal 
      proliferation of plasma cells, which synthesize abnormal monoclonal 
      immunoglobulin light chains. LCDD is characterized by systemic deposition of 
      light chains in various organs, with the kidneys being most commonly affected. 
      There have been few reports of isolated LCDD. We report a rare case of LCDD 
      limited to a duodenal polyp. A 63-yr-old man visited our hospital for health 
      screening without symptoms in 2009. On gastrofiberscopy, a duodenal polyp was 
      observed. The biopsy showed diffuse infiltration by atypical plasma cells, which 
      were positive for kappa-type light chains by immunohistochemistry. While the 
      patient refused further management, we could find no evidence of recurrence until 
      2 yr after the initial diagnosis. It has been reported that isolated LCDD has 
      relatively good prognosis compared to systemic LCDD. However, treatment for this 
      disease has not been established yet.
FAU - Kim, Hee-Jun
AU  - Kim HJ
AD  - Division of Hemato-Oncology, Department of Internal Medicine, Chung-Ang 
      University College of Medicine, Seoul, Korea.
FAU - Park, Eunkyung
AU  - Park E
FAU - Lee, Tae Jin
AU  - Lee TJ
FAU - Do, Jae Hyuk
AU  - Do JH
FAU - Cha, Young Joo
AU  - Cha YJ
FAU - Lee, Sang Jae
AU  - Lee SJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120127
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Immunoglobulin kappa-Chains)
SB  - IM
MH  - Duodenum/pathology
MH  - Endoscopy, Gastrointestinal
MH  - Humans
MH  - Immunoglobulin kappa-Chains/*immunology/metabolism
MH  - Immunohistochemistry
MH  - Intestinal Mucosa/*pathology
MH  - Male
MH  - Middle Aged
MH  - Paraproteinemias/*diagnosis/pathology
MH  - Tomography, X-Ray Computed
PMC - PMC3271296
OTO - NOTNLM
OT  - Duodenal Polyp
OT  - Isolated LCDD
OT  - Light Chain Deposition Disease (LCDD)
EDAT- 2012/02/11 06:00
MHDA- 2012/06/01 06:00
PMCR- 2012/02/01
CRDT- 2012/02/11 06:00
PHST- 2011/09/05 00:00 [received]
PHST- 2011/11/04 00:00 [accepted]
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
PHST- 2012/02/01 00:00 [pmc-release]
AID - 10.3346/jkms.2012.27.2.207 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2012 Feb;27(2):207-10. doi: 10.3346/jkms.2012.27.2.207. Epub 
      2012 Jan 27.