PMID- 22323980
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2092-7193 (Electronic)
IS  - 2092-7193 (Linking)
VI  - 34
DP  - 2012
TI  - Persistent organic pollutants and obesity-related metabolic dysfunction: focusing 
      on type 2 diabetes.
PG  - e2012002
LID - 10.4178/epih/e2012002 [doi]
LID - e2012002
AB  - Even though obesity is a well-established risk factor of type 2 diabetes, there 
      is emerging evidence that persistent organic pollutants (POPs), a variety of 
      lipophilic chemicals accumulated in adipose tissue, may be critically involved in 
      the pathogenesis of type 2 diabetes. Among various POPs, serum concentrations of 
      organochlorine pesticides and polychlorinated biphenyls (PCBs) were the most 
      strongly and consistently linked to type 2 diabetes in both cross-sectional and 
      prospective studies. In particular, obesity did not seem to be related to type 2 
      diabetes among persons with very low serum concentrations of POPs, suggesting a 
      more fundamental role of chlorinated POPs in the pathogenesis of type 2 diabetes. 
      These POPs were also associated with obesity, insulin resistance, and adverse 
      lipid profiles like high triglyceride and low high-density lipoprotein (HDL) 
      cholesterol among persons without diabetes, all metabolic dysfunctions commonly 
      observed before developing type 2 diabetes. Recent animal studies supported the 
      findings from epidemiological studies. If all these findings on POPs are true, it 
      suggests that any effort to reduce the external and internal exposure to POPs 
      would be necessary to decrease the social burden of type 2 diabetes.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventive Medicine, Kyungpook National University School of 
      Medicine, Daegu, Korea.
LA  - eng
PT  - Journal Article
DEP - 20120127
PL  - Korea (South)
TA  - Epidemiol Health
JT  - Epidemiology and health
JID - 101519472
PMC - PMC3272548
OTO - NOTNLM
OT  - Diabetes
OT  - Obesity
OT  - Organochlorine pesticides
OT  - Persistent organic pollutants
OT  - Polychlorinated biphenyl
EDAT- 2012/02/11 06:00
MHDA- 2012/02/11 06:01
PMCR- 2012/01/27
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2012/02/11 06:01 [medline]
PHST- 2012/01/27 00:00 [pmc-release]
AID - 10.4178/epih/e2012002 [doi]
PST - ppublish
SO  - Epidemiol Health. 2012;34:e2012002. doi: 10.4178/epih/e2012002. Epub 2012 Jan 27.