PMID- 22324941
OWN - NLM
STAT- MEDLINE
DCOM- 20120622
LR  - 20181201
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 15
IP  - 1
DP  - 2012 Feb
TI  - Does HLA-B*2706 protect against ankylosing spondylitis? A meta-analysis.
PG  - 8-12
LID - 10.1111/j.1756-185X.2011.01676.x [doi]
AB  - The human leukocyte antigen (HLA)-B*2706 is a relatively rare subtype of HLA-B27. 
      In contrast to most HLA-B27 subtypes, some studies have reported HLA-B*2706 to be 
      protective against ankylosing spondylitis (AS). A systematic review and a 
      meta-analysis of available studies was performed to investigate the association 
      of HLA-B*2706 with AS. After literature review a random effect meta-analysis was 
      performed. No studies were found comparing the frequency of HLA-B*2706 in AS 
      patients and controls. Meta-analysis of seven studies using HLA-B27-positive AS 
      patients and controls showed a protective effect of HLA-B*2706 on development of 
      AS in HLA-B27 individuals (odds ratio = 0.128, 95% CI = 0.043-0.378, P < 0.001). 
      The results of the meta-analysis of HLA-B*2706 in HLA-B27-positive patients and 
      controls is preliminary evidence of a protective effect of HLA-B*2706 against AS 
      in the population. There is a clear need for additional studies on HLA-B*2706 in 
      AS. Due to the fact that HLA-B*2706 is more or less restricted to Southeast Asia, 
      researchers in this part of the world may have an essential role in performing 
      these studies.
CI  - (c) 2011 The Author. International Journal of Rheumatic Diseases (c) 2011 Asia 
      Pacific League of Associations for Rheumatology and Blackwell Publishing Asia Pty 
      Ltd.
FAU - Van Gaalen, Floris Alexander
AU  - Van Gaalen FA
AD  - Department of Rheumatology, Leiden University Medical Center, Leiden, The 
      Netherlands. f.a.van_gaalen@lumc.nl
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20111018
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (HLA-B*27:06 antigen)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Case-Control Studies
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-B27 Antigen/*genetics
MH  - Humans
MH  - Odds Ratio
MH  - Phenotype
MH  - Risk Assessment
MH  - Risk Factors
MH  - Spondylitis, Ankylosing/epidemiology/*genetics/immunology/*prevention & control
EDAT- 2012/02/14 06:00
MHDA- 2012/06/23 06:00
CRDT- 2012/02/14 06:00
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/06/23 06:00 [medline]
AID - 10.1111/j.1756-185X.2011.01676.x [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2012 Feb;15(1):8-12. doi: 10.1111/j.1756-185X.2011.01676.x. Epub 
      2011 Oct 18.