PMID- 22325821
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20240503
IS  - 1364-8594 (Electronic)
IS  - 0003-4983 (Print)
IS  - 0003-4983 (Linking)
VI  - 105
IP  - 8
DP  - 2011 Dec
TI  - Prevalence of Strongyloides stercoralis infection among HIV-positive immigrants 
      attending two Italian hospitals, from 2000 to 2009.
PG  - 617-23
LID - 10.1179/2047773211Y.0000000006 [doi]
AB  - In patients with Strongyloides stercoralis infection, a dysregulation of host 
      immunity can lead to hyperinfection syndrome (HS) and disseminated 
      strongyloidiasis (DS), characterized by high fatality rate. HS has been reported 
      in HIV-positive patients following use of corticosteroids or during immune 
      reconstitution inflammatory syndrome (IRIS). A retrospective study was conducted 
      to estimate the prevalence of S. stercoralis infection among HIV-positive 
      immigrants, attending two Italian hospitals. From January 2000 to August 2009, 
      138 HIV-positive immigrants were systematically screened for strongyloidiasis, as 
      a part of their routine care, with an indirect immunofluorescent antibody test 
      (IFAT) developed at the Centre for Tropical Diseases, Sacro Cuore Hospital of 
      Negrar, Verona. The majority were also submitted to stool examination. Fifteen 
      (11%) resulted infected by S. stercoralis, of whom four (27%) had a negative 
      serology (diagnosis made with stool examination). A higher eosinophil count (0.94 
      versus 0.24x10(9)/l, P<0.01) and more frequent gastrointestinal and cutaneous 
      symptoms (odds ratio: 4.8 and 5.8, respectively) were found in patients with 
      strongyloidiasis compared with controls. The IFAT is more sensitive than direct 
      parasitological methods. The proportion of false negative results was higher than 
      expected based on the theoretical test sensitivity. Considering the high 
      prevalence detected and the apparent, lower sensitivity of serology, we propose a 
      systematic screening for Strongyloides infection, with both serology and stool 
      culture, for all HIV-positive immigrants coming from endemic areas.
FAU - Mascarello, M
AU  - Mascarello M
AD  - Policlinico GB Rossi, University of Verona, Italy. martamasca@yahoo.it
FAU - Gobbi, F
AU  - Gobbi F
FAU - Angheben, A
AU  - Angheben A
FAU - Gobbo, M
AU  - Gobbo M
FAU - Gaiera, G
AU  - Gaiera G
FAU - Pegoraro, M
AU  - Pegoraro M
FAU - Lanzafame, M
AU  - Lanzafame M
FAU - Buonfrate, D
AU  - Buonfrate D
FAU - Concia, E
AU  - Concia E
FAU - Bisoffi, Z
AU  - Bisoffi Z
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Ann Trop Med Parasitol
JT  - Annals of tropical medicine and parasitology
JID - 2985178R
SB  - IM
MH  - AIDS-Related Opportunistic 
      Infections/complications/diagnosis/*ethnology/immunology
MH  - Adult
MH  - Animals
MH  - Black People/statistics & numerical data
MH  - CD4 Lymphocyte Count
MH  - Emigrants and Immigrants/statistics & numerical data
MH  - False Negative Reactions
MH  - Feces/parasitology
MH  - Female
MH  - Fluorescent Antibody Technique, Indirect/methods
MH  - Humans
MH  - Italy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retrospective Studies
MH  - *Strongyloides stercoralis
MH  - Strongyloidiasis/complications/diagnosis/*ethnology/immunology
MH  - Young Adult
PMC - PMC4089805
EDAT- 2012/02/14 06:00
MHDA- 2012/04/26 06:00
PMCR- 2012/12/01
CRDT- 2012/02/14 06:00
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - 178 [pii]
AID - 10.1179/2047773211Y.0000000006 [doi]
PST - ppublish
SO  - Ann Trop Med Parasitol. 2011 Dec;105(8):617-23. doi: 
      10.1179/2047773211Y.0000000006.