PMID- 22327391
OWN - NLM
STAT- MEDLINE
DCOM- 20120622
LR  - 20120430
IS  - 1432-8798 (Electronic)
IS  - 0304-8608 (Linking)
VI  - 157
IP  - 5
DP  - 2012 May
TI  - Natural infection with torque teno sus virus 1 (TTSuV1) suppresses the immune 
      response to porcine reproductive and respiratory syndrome virus (PRRSV) 
      vaccination.
PG  - 927-33
LID - 10.1007/s00705-012-1249-3 [doi]
AB  - To evaluate the effect of natural infection with TTSuV1 on the antibody response 
      to vaccination with PRRS vaccine and clinical signs when co-infected with 
      virulent PRRSV, 15 4-week-old TTSuV1-positive piglets and 20 TTSuV1-negative 
      piglets were selected by PCR from two pig farms in Jiangsu province. 
      TTSuV1-negative pigs were divided into four groups, and TTSuV1-positive pigs were 
      divided into three groups. Experimental pigs were vaccinated with a PRRSV 
      modified live virus (MLV) at 6 weeks of age and subsequently challenged with a 
      virulent strain of PRRSV at 10 weeks of age. A TTSuV1-negative control group and 
      an unvaccinated PRRS MLV control group were tested at the same time. The levels 
      of antibody/cytokine and protective efficiency against PRRS MLV vaccine were 
      evaluated. TTSuV1-infected/PRRSV-vaccinated pigs had lower levels of PRRSV 
      antibody, as well as IFN-gamma, IL-10 and T lymphocyte proliferation, than the 
      TTSuV1-uninfected/PRRSV-vaccinated group (P < 0.05, except IL-10) after 
      vaccination at only one time point. TTSuV1-infected/PRRS 
      MLV-vaccinated/PRRSV-challenged pigs had more severe clinical signs (P > 0.05), 
      more macroscopic lung lesions (P < 0.05) and lower levels of PRRSV antibody (P < 
      0.05 at 7 to 14 days post-PRRSV-challenge) than 
      TTSuV1-uninfected/PRRSV-vaccinated/PRRSV-challenged pigs. These data indicate 
      that TTSuV1 natural infection has an adverse effect on the development of host 
      immune responses, suppresses immunization by the PRRS MLV vaccine, and 
      exacerbates PRRS to a certain extent in pigs.
FAU - Zhang, Zhicheng
AU  - Zhang Z
AD  - Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing Agricultural 
      University, Nanjing 210095, China.
FAU - Wang, Yang
AU  - Wang Y
FAU - Fan, Hongjie
AU  - Fan H
FAU - Lu, Chengping
AU  - Lu C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120211
PL  - Austria
TA  - Arch Virol
JT  - Archives of virology
JID - 7506870
RN  - 0 (Antibodies, Viral)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/immunology
MH  - *Down-Regulation
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology/*prevention & 
      control/virology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology/physiology
MH  - Swine
MH  - Torque teno virus/genetics/immunology/isolation & purification/*physiology
MH  - Vaccination
MH  - Viral Vaccines/administration & dosage/*immunology
EDAT- 2012/02/14 06:00
MHDA- 2012/06/23 06:00
CRDT- 2012/02/14 06:00
PHST- 2011/12/02 00:00 [received]
PHST- 2012/01/10 00:00 [accepted]
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/06/23 06:00 [medline]
AID - 10.1007/s00705-012-1249-3 [doi]
PST - ppublish
SO  - Arch Virol. 2012 May;157(5):927-33. doi: 10.1007/s00705-012-1249-3. Epub 2012 Feb 
      11.