PMID- 22327939 OWN - NLM STAT- MEDLINE DCOM- 20130422 LR - 20211021 IS - 1875-8312 (Electronic) IS - 1569-5794 (Linking) VI - 28 IP - 8 DP - 2012 Dec TI - Correlation of left ventricular wall thickness, heart mass, serological parameters and late gadolinium enhancement in cardiovascular magnetic resonance imaging of myocardial inflammation in an experimental animal model of autoimmune myocarditis. PG - 1983-97 LID - 10.1007/s10554-012-0020-x [doi] AB - For a definitive diagnosis of myocarditis, different strategies like analysis of late gadolinium enhancement (LGE) in cardiovascular magnetic resonance imaging (CMR) up to invasive endomyocardial biopsy have been applied. The objective of the study was to investigate inflammatory changes like left ventricular wall thickening and increase of ventricular mass and to quantitatively analyse their correlation with extent and localisation of myocardial damage in CMR and with subsequent changes of serological markers in an animal model of an experimental autoimmune myocarditis (EAM). In the current study, an EAM was induced in 10 male Lewis rats, 10 rats served as control. On day 21, animals were examined with four CMR protocols to assess the extent of LGE in a 12 segment model of the rat heart. Left myocardial wall thickness and mass and histological grade of inflammation were measured to determine localisation and severity of the induced myocarditis. Depending on the CMR sequence, LGE was mostly found in the left anterior (9.6%) and left lateral (8.7%) myocardial wall segments. Wall thickness correlated with the LGE area in CMR imaging and the histopathological severity of myocarditis for the left lateral myocardial wall segment. In a similar way, the heart mass correlated to the extent of LGE for the left lateral segment. We conclude that in our animal model left ventricular wall thickness and mass reflect the severity of myocardial changes in myocarditis and that the EAM rat model is well suited for further investigations of myocarditis. FAU - Kromen, Wolfgang AU - Kromen W AD - Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. wolfgang.kromen@kgu.de FAU - Korkusuz, Huedayi AU - Korkusuz H FAU - Korkusuz, Yuecel AU - Korkusuz Y FAU - Esters, Philip AU - Esters P FAU - Bauer, Ralf W AU - Bauer RW FAU - Huebner, Frank AU - Huebner F FAU - Lindemayr, Sebastian AU - Lindemayr S FAU - Vogl, Thomas J AU - Vogl TJ LA - eng PT - Journal Article DEP - 20120212 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Biomarkers) RN - 0 (Contrast Media) RN - 0 (Haptoglobins) RN - 0 (Hp protein, rat) RN - 0 (Troponin T) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Animals MH - Autoimmune Diseases/blood/*diagnosis/immunology/pathology MH - Biomarkers/blood MH - *Contrast Media MH - Disease Models, Animal MH - *Gadolinium DTPA MH - Haptoglobins/metabolism MH - Heart Ventricles/immunology/*pathology MH - *Magnetic Resonance Imaging MH - Male MH - Myocarditis/blood/*diagnosis/immunology/pathology MH - Predictive Value of Tests MH - Rats MH - Rats, Inbred Lew MH - Severity of Illness Index MH - Time Factors MH - Troponin T/blood EDAT- 2012/02/14 06:00 MHDA- 2013/04/23 06:00 CRDT- 2012/02/14 06:00 PHST- 2011/08/09 00:00 [received] PHST- 2012/01/17 00:00 [accepted] PHST- 2012/02/14 06:00 [entrez] PHST- 2012/02/14 06:00 [pubmed] PHST- 2013/04/23 06:00 [medline] AID - 10.1007/s10554-012-0020-x [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2012 Dec;28(8):1983-97. doi: 10.1007/s10554-012-0020-x. Epub 2012 Feb 12.