PMID- 22327941
OWN - NLM
STAT- MEDLINE
DCOM- 20130422
LR  - 20211021
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 28
IP  - 8
DP  - 2012 Dec
TI  - Diagnostic accuracy of global myocardial deformation indexes in coronary artery 
      disease: a velocity vector imaging study.
PG  - 1931-42
LID - 10.1007/s10554-012-0025-5 [doi]
AB  - The aim of our study was to assess the diagnostic accuracy of a global 
      longitudinal strain and strain rate (GLS, GLSR) and mean radial strain and strain 
      rate (MRS, MRSR) of the left ventricle to predict multivessel disease. In 113 
      patients, who underwent coronary angiography, left ventricular deformation was 
      analysed by speckle-tracking based velocity vector imaging. In three standard 
      apical views strain and strain rate curves were generated corresponding with two 
      opposite basal, mid, and apical segments. The negative peaks of systolic strain 
      and strain rate from 18 curves were averaged as GLS and GLSR. Similarly, in short 
      axis view 6 negative systolic peaks were averaged and considered as MRS and MRSR. 
      Four subgroups were defined: (1) without significant coronary stenosis, 0-vessel 
      disease (0VD), (2) single-vessel disease (1VD), (3) double-vessel disease (2VD), 
      and (4) triple-vessel disease (3VD). In comparison with patients without 
      significant coronary artery disease, all deformation indexes were significantly 
      decreased in patients with 3VD. The left ventricular ejection fraction (LVEF) and 
      wall motion score index (WMSI) showed lower significance level as deformation 
      parameters. MRSR was the strongest predictor of multivessel disease. 
      Receiver-operating characteristic curves (ROC) showed that MRSR had the highest 
      diagnostic accuracy. Comparing ROC areas, MRSR had significantly higher 
      diagnostic accuracy than LVEF and WMSI. The results of our study show that global 
      deformation indexes have a good diagnostic accuracy in differentiating 
      multivessel disease. MRSR tended to be better in identification of 3VD than 
      traditional indexes of global and regional left ventricular function.
FAU - Valocik, Gabriel
AU  - Valocik G
AD  - Department of Cardiology, East Slovakian Institute of Cardiovascular Disease and 
      Safarik University, Kosice, Slovakia. gabriel.valocik@upjs.sk
FAU - Valocikova, Ivana
AU  - Valocikova I
FAU - Mitro, Peter
AU  - Mitro P
FAU - Fojtikova, Livia
AU  - Fojtikova L
FAU - Druzbacka, Ludmila
AU  - Druzbacka L
FAU - Kristofova, Beata
AU  - Kristofova B
FAU - Juhas, Stanislav
AU  - Juhas S
FAU - Kolesar, Adrian
AU  - Kolesar A
FAU - Sabol, Frantisek
AU  - Sabol F
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20120212
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*diagnostic imaging/physiopathology
MH  - *Echocardiography, Doppler
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Linear Models
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - *Myocardial Contraction
MH  - Observer Variation
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - *Ventricular Function, Left
EDAT- 2012/02/14 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/02/14 06:00
PHST- 2011/06/06 00:00 [received]
PHST- 2012/01/26 00:00 [accepted]
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - 10.1007/s10554-012-0025-5 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2012 Dec;28(8):1931-42. doi: 10.1007/s10554-012-0025-5. 
      Epub 2012 Feb 12.