PMID- 22329476
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20211021
IS  - 1399-5618 (Electronic)
IS  - 1398-5647 (Print)
IS  - 1398-5647 (Linking)
VI  - 14
IP  - 1
DP  - 2012 Feb
TI  - Pollen-specific immunoglobulin E positivity is associated with worsening of 
      depression scores in bipolar disorder patients during high pollen season.
PG  - 90-8
LID - 10.1111/j.1399-5618.2012.00983.x [doi]
AB  - OBJECTIVE: An association between allergic disease and depression has been 
      consistently reported, but whether the key mediating ingredients are 
      predominantly biological, psychological, or mere artifacts remains unknown. In 
      the current study, we examined a hypothesized relationship between 
      allergen-specific immunoglobulin E (IgE) status and changes in allergy symptoms 
      with worsening in depression scores. METHODS: In patients with recurrent mood 
      disorders, we individually coupled sensitization to specific seasonal 
      aeroallergens (as assessed by allergen-specific IgE) with temporal windows of 
      exposure to aeroallergens (low versus high tree or ragweed pollen counts, 
      measured according to the National Allergy Bureau guidelines). We compared 
      Structured Interview Guide for the Hamilton Depression Rating Scale-Seasonal 
      Affective Disorder Version (SIGH-SAD) depression score changes in 41 patients 
      with mood disorders [25 with major depression and 16 with bipolar I disorder, 
      diagnosed by Structured Clinical Interview for DSM (SCID)] seropositive for tree 
      or ragweed pollen-specific IgE antibody versus 53 patients with mood disorders 
      (30 with major depression and 23 with bipolar I disorder) seronegative for 
      aeroallergen-specific IgE. RESULTS: Worsening in total depressive scores from low 
      to high pollen exposure was greater in allergen-specific IgE-positive patients as 
      compared to allergen-specific IgE antibody-negative patients (p = 0.01). When 
      stratified by polarity, the association was significant only in patients with 
      bipolar I disorder (p = 0.004). This relationship was resilient to adjustment for 
      changes in allergy symptom scores. CONCLUSION: To our knowledge, this is the 
      first report of coupling a molecular marker of vulnerability (allergen-specific 
      IgE) with a specific environmental trigger (airborne allergens) leading to 
      exacerbation of depression in patients with bipolar I disorder.
CI  - (c) 2012 John Wiley and Sons A/S.
FAU - Manalai, Partam
AU  - Manalai P
AD  - Mood and Anxiety Program, Department of Psychiatry, University of Maryland at 
      Baltimore, Baltimore, MD, USA.
FAU - Hamilton, Robert G
AU  - Hamilton RG
FAU - Langenberg, Patricia
AU  - Langenberg P
FAU - Kosisky, Susan E
AU  - Kosisky SE
FAU - Lapidus, Manana
AU  - Lapidus M
FAU - Sleemi, Aamar
AU  - Sleemi A
FAU - Scrandis, Debra
AU  - Scrandis D
FAU - Cabassa, Johanna A
AU  - Cabassa JA
FAU - Rogers, Christine A
AU  - Rogers CA
FAU - Regenold, William T
AU  - Regenold WT
FAU - Dickerson, Faith
AU  - Dickerson F
FAU - Vittone, Bernard J
AU  - Vittone BJ
FAU - Guzman, Alvaro
AU  - Guzman A
FAU - Balis, Theodora
AU  - Balis T
FAU - Tonelli, Leonardo H
AU  - Tonelli LH
FAU - Postolache, Teodor T
AU  - Postolache TT
LA  - eng
GR  - R21 MH075891-01A1/MH/NIMH NIH HHS/United States
GR  - M01 RR16500/RR/NCRR NIH HHS/United States
GR  - M01 RR016500/RR/NCRR NIH HHS/United States
GR  - R01 MH074891/MH/NIMH NIH HHS/United States
GR  - R21 MH075891/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/*immunology
MH  - Ambrosia/immunology
MH  - Bipolar Disorder/*immunology/psychology
MH  - Depression/*immunology/psychology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Pollen/*immunology
MH  - Rhinitis, Allergic, Seasonal/*psychology
MH  - Seasons
MH  - Severity of Illness Index
MH  - Trees/immunology
PMC - PMC3293700
MID - NIHMS348111
COIS- Disclosures The authors of this paper do not have any commercial associations 
      that might pose a conflict of interest in connection with this manuscript.
EDAT- 2012/02/15 06:00
MHDA- 2012/06/05 06:00
PMCR- 2013/02/01
CRDT- 2012/02/15 06:00
PHST- 2012/02/15 06:00 [entrez]
PHST- 2012/02/15 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
PHST- 2013/02/01 00:00 [pmc-release]
AID - 10.1111/j.1399-5618.2012.00983.x [doi]
PST - ppublish
SO  - Bipolar Disord. 2012 Feb;14(1):90-8. doi: 10.1111/j.1399-5618.2012.00983.x.