PMID- 22329740
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20120615
IS  - 1462-5822 (Electronic)
IS  - 1462-5814 (Linking)
VI  - 14
IP  - 7
DP  - 2012 Jul
TI  - Interaction networks of hepatitis C virus NS4B: implications for antiviral 
      therapy.
PG  - 994-1002
LID - 10.1111/j.1462-5822.2012.01773.x [doi]
AB  - Hepatitis C virus (HCV) is an important human pathogen infecting more than 170 
      million people worldwide with approximately three million new cases each year. 
      HCV depends heavily on interactions between viral proteins and host factors for 
      its survival and propagation. Among HCV viral proteins, the HCV non-structural 
      protein 4B (NS4B) has been shown to mediate virus-host interactions that are 
      essential for HCV replication and pathogenesis and emerged as the target for 
      anti-HCV therapy. Here, we reviewed recent knowledge about the NS4B interaction 
      networks with host factors and its possible regulatory mechanisms, which will 
      both advance our understanding of the role of NS4B in HCV life cycle and 
      illuminate potential viral and host therapeutic targets.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Li, Shanshan
AU  - Li S
AD  - Department of Plant Pathology and Microbiology, Iowa State University, Ames, IA, 
      USA.
FAU - Yu, Xilan
AU  - Yu X
FAU - Guo, Yunli
AU  - Guo Y
FAU - Kong, Lingbao
AU  - Kong L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120305
PL  - India
TA  - Cell Microbiol
JT  - Cellular microbiology
JID - 100883691
RN  - 0 (Antiviral Agents)
RN  - 0 (NS4B protein, flavivirus)
RN  - 0 (Viral Nonstructural Proteins)
SB  - IM
MH  - Antiviral Agents/*pharmacology
MH  - Hepacivirus/*drug effects/*pathogenicity/physiology
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - *Protein Interaction Mapping
MH  - Viral Nonstructural Proteins/*metabolism
MH  - Virus Replication/*drug effects
EDAT- 2012/02/15 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/02/15 06:00
PHST- 2012/02/15 06:00 [entrez]
PHST- 2012/02/15 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - 10.1111/j.1462-5822.2012.01773.x [doi]
PST - ppublish
SO  - Cell Microbiol. 2012 Jul;14(7):994-1002. doi: 10.1111/j.1462-5822.2012.01773.x. 
      Epub 2012 Mar 5.