PMID- 22331332
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20230215
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Print)
IS  - 0031-4005 (Linking)
VI  - 129
IP  - 3
DP  - 2012 Mar
TI  - Nonconvulsive status epilepticus: the encephalopathic pediatric patient.
PG  - e748-55
LID - 10.1542/peds.2011-2067 [doi]
AB  - OBJECTIVE: A high prevalence of nonconvulsive status epilepticus (NCSE) has been 
      reported in critically ill adults and neonates. Recent prospective pediatric 
      studies focus on critically ill children and show wide variability in the 
      frequency of NCSE. This study examines prevalence of pediatric NCSE regardless of 
      inpatient setting and retrospectively identifies risk factors indicating a need 
      for urgent continuous EEG. METHODS: Medical records from patients aged 3 months 
      to 21 years were identified either by (1) searching a clinical EEG database (n = 
      18) or (2) consecutive inpatient EEG referrals for NCSE over an 8-month period (n 
      = 57). RESULTS: Seventy-five children, mean age of 7.8 years, were studied. NCSE 
      was identified in 26 patients (35%) and in 8 of 57 (14%) patients referred for 
      possible NCSE. More than half of the patients referred were outside of the ICU. A 
      witnessed clinical seizure was observed in 24 of 26 (92%) patients with NCSE. 
      Acute cortical neuroimaging abnormalities were significantly more frequent in 
      patients with NCSE. The presence of clinical seizures and acute neuroimaging 
      abnormality was associated with an 82% probability of NCSE. All but 1 patient 
      with NCSE had electrographic or electroclinical seizures within the first hour of 
      monitoring. CONCLUSIONS: A high prevalence of NCSE was observed, comparable to 
      adult studies, but within a wider range of inpatient settings. Children with 
      acute encephalopathy should undergo continuous EEG. This evaluation is more 
      urgent if certain clinical risk factors are present. Optimal duration of 
      monitoring and the effect of NCSE on prognosis should be studied.
FAU - Greiner, Hansel M
AU  - Greiner HM
AD  - Division of Child Neurology, Department of Pediatrics, Cincinnati Children's 
      Hospital Medical Center, Cincinnati, OH 45229, USA. hansel.greiner@cchmc.org
FAU - Holland, Katherine
AU  - Holland K
FAU - Leach, James L
AU  - Leach JL
FAU - Horn, Paul S
AU  - Horn PS
FAU - Hershey, Andrew D
AU  - Hershey AD
FAU - Rose, Douglas F
AU  - Rose DF
LA  - eng
GR  - R01 NS062756/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
DEP - 20120213
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Anticonvulsants/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Electroencephalography/*methods
MH  - Female
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Male
MH  - Monitoring, Physiologic/methods
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Sex Distribution
MH  - Status Epilepticus/*diagnosis/drug therapy/*epidemiology
MH  - Survival Rate
MH  - United States/epidemiology
PMC - PMC9923578
COIS- FINANCIAL DISCLOSURE: The authors have indicated they have no financial 
      relationships relevant to this article to disclose.
EDAT- 2012/02/15 06:00
MHDA- 2012/04/26 06:00
PMCR- 2013/03/01
CRDT- 2012/02/15 06:00
PHST- 2012/02/15 06:00 [entrez]
PHST- 2012/02/15 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
PHST- 2013/03/01 00:00 [pmc-release]
AID - peds.2011-2067 [pii]
AID - peds.2011-2067.129.3.e748 [pii]
AID - 10.1542/peds.2011-2067 [doi]
PST - ppublish
SO  - Pediatrics. 2012 Mar;129(3):e748-55. doi: 10.1542/peds.2011-2067. Epub 2012 Feb 
      13.