PMID- 22332193
OWN - NLM
STAT- MEDLINE
DCOM- 20120409
LR  - 20240315
IS  - 1538-3687 (Electronic)
IS  - 0003-9942 (Print)
IS  - 0003-9942 (Linking)
VI  - 69
IP  - 2
DP  - 2012 Feb
TI  - Mediterranean diet and white matter hyperintensity volume in the Northern 
      Manhattan Study.
PG  - 251-6
LID - 10.1001/archneurol.2011.548 [doi]
AB  - OBJECTIVE: To examine the association between a Mediterranean-style diet (MeDi) 
      and brain magnetic resonance imaging white matter hyperintensity volume (WMHV). 
      DESIGN: A cross-sectional analysis within a longitudinal population-based cohort 
      study. A semiquantitative food frequency questionnaire was administered, and a 
      score (range, 0-9) was calculated to reflect increasing similarity to the MeDi 
      pattern. SETTING: The Northern Manhattan Study. PARTICIPANTS: A total of 1091 
      participants, of whom 966 had dietary information (mean age, 72 years; 59.3% 
      women, 64.6% Hispanic, 15.6% white, and 17.5% black). MAIN OUTCOME MEASURES: The 
      WMHV was measured by quantitative brain magnetic resonance imaging. Linear 
      regression models were constructed to examine the association between the MeDi 
      score and the log-transformed WMHV as a proportion of total cranial volume, 
      controlling for sociodemographic and vascular risk factors. RESULTS: On the MeDi 
      scale, 11.6% scored 0 to 2, 15.8% scored 3, 23.0% scored 4, 23.5% scored 5, and 
      26.1% scored 6 to 9. Each 1-point increase in MeDi score was associated with a 
      lower log WMHV (beta = -.04, P = .01). The only MeDi score component that was an 
      independent predictor of WMHV was the ratio of monounsaturated to saturated fat 
      (beta = -.20, P = .001). CONCLUSIONS: A MeDi was associated with a lower WMHV 
      burden, a marker of small vessel damage in the brain. However, white matter 
      hyperintensities are etiologically heterogenous and can include 
      neurodegeneration. Replication by other population-based studies is needed.
FAU - Gardener, Hannah
AU  - Gardener H
AD  - Department of Neurology, Miller School of Medicine, University of Miami, Miami, 
      FL 33136, USA.
FAU - Scarmeas, Nikolaos
AU  - Scarmeas N
FAU - Gu, Yian
AU  - Gu Y
FAU - Boden-Albala, Bernadette
AU  - Boden-Albala B
FAU - Elkind, Mitchell S V
AU  - Elkind MS
FAU - Sacco, Ralph L
AU  - Sacco RL
FAU - DeCarli, Charles
AU  - DeCarli C
FAU - Wright, Clinton B
AU  - Wright CB
LA  - eng
GR  - K02 NS059729-04/NS/NINDS NIH HHS/United States
GR  - K02 NS 059729/NS/NINDS NIH HHS/United States
GR  - R37 NS029993/NS/NINDS NIH HHS/United States
GR  - K02 NS059729/NS/NINDS NIH HHS/United States
GR  - R37 NS029993-20/NS/NINDS NIH HHS/United States
GR  - R37 NS 29993/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Neurol
JT  - Archives of neurology
JID - 0372436
RN  - 0 (Lipids)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Blood Pressure/physiology
MH  - Body Mass Index
MH  - Brain/*anatomy & histology
MH  - Cerebral Small Vessel Diseases/pathology
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Data Interpretation, Statistical
MH  - Diabetes Mellitus/epidemiology
MH  - *Diet, Mediterranean
MH  - Feeding Behavior
MH  - Female
MH  - Humans
MH  - Life Style
MH  - Lipids/blood
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Motor Activity/physiology
MH  - New York City
MH  - Risk Factors
MH  - Risk Reduction Behavior
MH  - Socioeconomic Factors
MH  - Vascular Diseases/epidemiology
PMC - PMC3281550
MID - NIHMS288322
EDAT- 2012/02/15 06:00
MHDA- 2012/04/10 06:00
PMCR- 2013/02/01
CRDT- 2012/02/15 06:00
PHST- 2012/02/15 06:00 [entrez]
PHST- 2012/02/15 06:00 [pubmed]
PHST- 2012/04/10 06:00 [medline]
PHST- 2013/02/01 00:00 [pmc-release]
AID - 69/2/251 [pii]
AID - 10.1001/archneurol.2011.548 [doi]
PST - ppublish
SO  - Arch Neurol. 2012 Feb;69(2):251-6. doi: 10.1001/archneurol.2011.548.