PMID- 22333441
OWN - NLM
STAT- MEDLINE
DCOM- 20120702
LR  - 20211021
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 12
DP  - 2012 Feb 14
TI  - Diagnostic accuracy of cyst fluid amphiregulin in pancreatic cysts.
PG  - 15
LID - 10.1186/1471-230X-12-15 [doi]
AB  - BACKGROUND: Accurate tests to diagnose adenocarcinoma and high-grade dysplasia 
      among mucinous pancreatic cysts are clinically needed. This study evaluated the 
      diagnostic utility of amphiregulin (AREG) as a pancreatic cyst fluid biomarker to 
      differentiate non-mucinous, benign mucinous, and malignant mucinous cysts. 
      METHODS: A single-center retrospective study to evaluate AREG levels in 
      pancreatic cyst fluid by ELISA from 33 patients with a histological gold standard 
      was performed. RESULTS: Among the cyst fluid samples, the median (IQR) AREG 
      levels for non-mucinous (n = 6), benign mucinous (n = 15), and cancerous cysts (n 
      = 15) were 85 pg/ml (47-168), 63 pg/ml (30-847), and 986 pg/ml (417-3160), 
      respectively. A significant difference between benign mucinous and malignant 
      mucinous cysts was observed (p = 0.025). AREG levels greater than 300 pg/ml 
      possessed a diagnostic accuracy for cancer or high-grade dysplasia of 78% 
      (sensitivity 83%, specificity 73%). CONCLUSION: Cyst fluid AREG levels are 
      significantly higher in cancerous and high-grade dysplastic cysts compared to 
      benign mucinous cysts. Thus AREG exhibits potential clinical utility in the 
      evaluation of pancreatic cysts.
FAU - Tun, May T
AU  - Tun MT
AD  - Department of Medicine, Stanford University, Stanford, CA 94305, USA.
FAU - Pai, Reetesh K
AU  - Pai RK
FAU - Kwok, Shirley
AU  - Kwok S
FAU - Dong, Aiwen
AU  - Dong A
FAU - Gupta, Aparna
AU  - Gupta A
FAU - Visser, Brendan C
AU  - Visser BC
FAU - Norton, Jeff A
AU  - Norton JA
FAU - Poultsides, George A
AU  - Poultsides GA
FAU - Banerjee, Subhas
AU  - Banerjee S
FAU - Van Dam, Jacques
AU  - Van Dam J
FAU - Chen, Ann M
AU  - Chen AM
FAU - Friedland, Shai
AU  - Friedland S
FAU - Scott, Brennan A
AU  - Scott BA
FAU - Verma, Rahul
AU  - Verma R
FAU - Lowe, Anson W
AU  - Lowe AW
FAU - Park, Walter G
AU  - Park WG
LA  - eng
GR  - DK063624/DK/NIDDK NIH HHS/United States
GR  - DK56339/DK/NIDDK NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120214
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - 0 (AREG protein, human)
RN  - 0 (Amphiregulin)
RN  - 0 (Biomarkers)
RN  - 0 (EGF Family of Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Adenocarcinoma/*diagnosis/metabolism
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amphiregulin
MH  - Biomarkers/metabolism
MH  - Cyst Fluid/*metabolism
MH  - Diagnosis, Differential
MH  - EGF Family of Proteins
MH  - Female
MH  - Glycoproteins/*metabolism
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Cyst/*diagnosis/metabolism
MH  - Pancreatic Neoplasms/*diagnosis/metabolism
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
PMC - PMC3305641
EDAT- 2012/02/16 06:00
MHDA- 2012/07/03 06:00
PMCR- 2012/02/14
CRDT- 2012/02/16 06:00
PHST- 2011/09/02 00:00 [received]
PHST- 2012/02/14 00:00 [accepted]
PHST- 2012/02/16 06:00 [entrez]
PHST- 2012/02/16 06:00 [pubmed]
PHST- 2012/07/03 06:00 [medline]
PHST- 2012/02/14 00:00 [pmc-release]
AID - 1471-230X-12-15 [pii]
AID - 10.1186/1471-230X-12-15 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2012 Feb 14;12:15. doi: 10.1186/1471-230X-12-15.