PMID- 22333544
OWN - NLM
STAT- MEDLINE
DCOM- 20120802
LR  - 20131121
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 91
IP  - 40
DP  - 2011 Nov 1
TI  - [Effects of inhaled aerosolized iloprost in adult patients with pulmonary 
      arterial hypertension on right heart functions].
PG  - 2832-6
AB  - OBJECTIVE: To explore the immediate effects of inhaled aerosolized iloprost on 
      right heart function in adult patients with pulmonary arterial hypertension 
      (PAH). METHODS: A total of 30 PAH patients were recruited. Right heart 
      catheterization and echocardiography were performed before and immediately after 
      the inhalation of iloprost (20 microg). RESULTS: After inhalation, the values of mean 
      pulmonary artery pressure (PAPm) and pulmonary vascular resistances (PVR) 
      decreased markedly (42.5 +/- 9.6 to 34.4 +/- 11.9 mm Hg, P < 0.001; 9.6 +/- 5.7 Wood 
      unit to 7.1 +/- 4.8 Wood unit, P < 0.001). And the value of tricuspid annular 
      systolic motion peak velocity (TASm) increased markedly [(10.7 +/- 2.1) cm/s vs 
      (11.9 +/- 2.5) cm/s, P < 0.01]. The baseline level of TASm was higher in acute 
      responders than non-responders [(12.0 +/- 2.2) cm/s vs (10.1 +/- 1.8) cm/s, P = 0.01] 
      and TASm increased markedly after inhalation in non-responders [(10.1 +/- 1.8) cm/s 
      vs (11.6 +/- 2.3) cm/s, P < 0.01]. CONCLUSION: The inhalation of iloprost decreases 
      the levels of PAPm and PVR and improve right heart functions in adult PAH 
      patients. For non-responders, right heart function is worse and more benefits may 
      be achieved after the inhalation of iloprost.
FAU - Guo, Xiao-xiao
AU  - Guo XX
AD  - Department of Cardiology & Rheumatology, Peking Union Medical College Hospital, 
      Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 
      100730, China.
FAU - Tian, Zhuang
AU  - Tian Z
FAU - Liu, Yong-tai
AU  - Liu YT
FAU - Wang, Qian
AU  - Wang Q
FAU - Li, Meng-tao
AU  - Li MT
FAU - Zeng, Xiao-feng
AU  - Zeng XF
FAU - Zhu, Wen-ling
AU  - Zhu WL
FAU - Fang, Quan
AU  - Fang Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Vasodilator Agents)
RN  - JED5K35YGL (Iloprost)
SB  - IM
MH  - Administration, Inhalation
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/drug therapy/*physiopathology
MH  - Iloprost/*administration & dosage/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Vasodilator Agents/*administration & dosage/therapeutic use
MH  - Ventricular Function, Right/*drug effects
MH  - Young Adult
EDAT- 2012/02/16 06:00
MHDA- 2012/08/03 06:00
CRDT- 2012/02/16 06:00
PHST- 2012/02/16 06:00 [entrez]
PHST- 2012/02/16 06:00 [pubmed]
PHST- 2012/08/03 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2011 Nov 1;91(40):2832-6.