PMID- 22337212
OWN - NLM
STAT- MEDLINE
DCOM- 20120815
LR  - 20220317
IS  - 1099-1557 (Electronic)
IS  - 1053-8569 (Linking)
VI  - 21
IP  - 5
DP  - 2012 May
TI  - Uses of proton pump inhibitors and hypomagnesemia.
PG  - 553-9
LID - 10.1002/pds.3224 [doi]
AB  - PURPOSE: Hypomagnesemia associated with proton pump inhibitor (PPI) therapy has 
      been documented in case reports. We performed a cross-sectional study to examine 
      the association between PPI use and serum magnesium (Mg) levels or 
      hypomagnesemia. METHODS: Data were extracted from hospitalized adults with basic 
      metabolic panels and/or serum magnesium levels available during the hospital 
      stays. The first Mg value was used for data analysis. Hypomagnesemia is defined 
      as levels less than 1.7 mg/dL (or 0.70 mmol/L). Multiple linear and logistic 
      regression analyses were used to assess the association between PPI use and Mg 
      levels or hypomagnesemia, respectively. RESULTS: Among study patients, PPI users 
      (n = 207) had a mean Mg level of 1.91[SD = 0.34] mg/dL, and non-users (n = 280) 
      2.00 (0.30) mg/dL, p = 0.004. PPI use was associated with lower serum Mg levels 
      (adjusted coefficient beta = -0.10, 95% CI = [-0.16, -0.04]) after adjusting for 
      confounders. PPI use was associated with risk of hypomagnesemia after adjusting 
      for confounders (adjusted OR = 2.50, 95% CI = [1.43, 4.36]). Both standard (1) 
      and high (2 or higher) defined daily dose units of PPI therapy were associated 
      with hypomagnesemia. CONCLUSIONS: PPI use was associated with lower serum Mg 
      levels and hypomagnesemia in a population of hospitalized adult patients. Our 
      study supports the general notion that long-term PPI use could be associated with 
      sub-clinical Mg insufficiency or deficiency status.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Gau, Jen-Tzer
AU  - Gau JT
AD  - Department of Geriatric Medicine/Gerontology, Ohio University Heritage College of 
      Osteopathic Medicine (OU-HCOM), Athens, OH 45701, USA. gau@ohio.edu
FAU - Yang, Yu-Xiao
AU  - Yang YX
FAU - Chen, Roger
AU  - Chen R
FAU - Kao, Tzu-Cheg
AU  - Kao TC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120215
PL  - England
TA  - Pharmacoepidemiol Drug Saf
JT  - Pharmacoepidemiology and drug safety
JID - 9208369
RN  - 0 (Proton Pump Inhibitors)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Linear Models
MH  - Logistic Models
MH  - Magnesium/*blood
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/administration & dosage/*adverse effects/therapeutic use
EDAT- 2012/02/18 06:00
MHDA- 2012/08/16 06:00
CRDT- 2012/02/17 06:00
PHST- 2011/09/29 00:00 [received]
PHST- 2012/01/02 00:00 [revised]
PHST- 2012/01/04 00:00 [accepted]
PHST- 2012/02/17 06:00 [entrez]
PHST- 2012/02/18 06:00 [pubmed]
PHST- 2012/08/16 06:00 [medline]
AID - 10.1002/pds.3224 [doi]
PST - ppublish
SO  - Pharmacoepidemiol Drug Saf. 2012 May;21(5):553-9. doi: 10.1002/pds.3224. Epub 
      2012 Feb 15.