PMID- 22337238 OWN - NLM STAT- MEDLINE DCOM- 20130204 LR - 20191210 IS - 1499-2752 (Electronic) IS - 0315-162X (Linking) VI - 39 IP - 5 DP - 2012 May TI - Assessing the performance of the Birmingham Vasculitis Activity Score at diagnosis for children with antineutrophil cytoplasmic antibody-associated vasculitis in A Registry for Childhood Vasculitis (ARChiVe). PG - 1088-94 LID - 10.3899/jrheum.111030 [doi] AB - OBJECTIVE: There are no validated tools for measuring disease activity in pediatric vasculitis. The Birmingham Vasculitis Activity Score (BVAS) is a valid disease activity tool in adult vasculitis. Version 3 (BVAS v.3) correlates well with physician's global assessment (PGA), treatment decision, and C-reactive protein in adults. The utility of BVAS v.3 in pediatric vasculitis is not known. We assessed the association of BVAS v.3 scores with PGA, treatment decision, and erythrocyte sedimentation rate (ESR) at diagnosis in pediatric antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: Children with AAV diagnosed between 2004 and 2010 at all ARChiVe centers were eligible. BVAS v.3 scores were calculated with a standardized online tool (www.vasculitis.org). Spearman's rank correlation coefficient (r(s)) was used to test the strength of association between BVAS v.3 and PGA, treatment decision, and ESR. RESULTS: A total of 152 patients were included. The physician diagnosis of these patients was predominantly granulomatosis with polyangiitis (n = 99). The median BVAS v.3 score was 18.0 (range 0-40). The BVAS v.3 correlations were r(s) = 0.379 (95% CI 0.233 to 0.509) with PGA, r(s) = 0.521 (95% CI 0.393 to 0.629) with treatment decision, and r(s) = 0.403 (95% CI 0.253 to 0.533) with ESR. CONCLUSION: Applied to children with AAV, BVAS v.3 had a weak correlation with PGA and moderate correlation with both ESR and treatment decision. Prospective evaluation of BVAS v.3 and/or pediatric-specific modifications to BVAS v.3 may be required before it can be formalized as a disease activity assessment tool in pediatric AAV. FAU - Morishita, Kimberly AU - Morishita K AD - British Columbia Children's Hospital, Vancouver, British Columbia, Canada. FAU - Li, Suzanne C AU - Li SC FAU - Muscal, Eyal AU - Muscal E FAU - Spalding, Steven AU - Spalding S FAU - Guzman, Jaime AU - Guzman J FAU - Uribe, America AU - Uribe A FAU - Abramson, Leslie AU - Abramson L FAU - Baszis, Kevin AU - Baszis K FAU - Benseler, Susanne AU - Benseler S FAU - Bowyer, Suzanne AU - Bowyer S FAU - Campillo, Sarah AU - Campillo S FAU - Chira, Peter AU - Chira P FAU - Hersh, Aimee O AU - Hersh AO FAU - Higgins, Gloria AU - Higgins G FAU - Eberhard, Anne AU - Eberhard A FAU - Ede, Kaleo AU - Ede K FAU - Imundo, Lisa AU - Imundo L FAU - Jung, Lawrence AU - Jung L FAU - Kim, Susan AU - Kim S FAU - Kingsbury, Daniel J AU - Kingsbury DJ FAU - Klein-Gitelman, Marisa AU - Klein-Gitelman M FAU - Lawson, Erica F AU - Lawson EF FAU - Lovell, Daniel J AU - Lovell DJ FAU - Mason, Thomas AU - Mason T FAU - McCurdy, Deborah AU - McCurdy D FAU - Nanda, Kabita AU - Nanda K FAU - Nassi, Lorien AU - Nassi L FAU - O'Neil, Kathleen M AU - O'Neil KM FAU - Rabinovich, Egla AU - Rabinovich E FAU - Ramsey, Suzanne E AU - Ramsey SE FAU - Reiff, Andreas AU - Reiff A FAU - Rosenkranz, Margalit AU - Rosenkranz M FAU - Schikler, Kenneth AU - Schikler K FAU - Stevens, Anne AU - Stevens A FAU - Wahezi, Dawn AU - Wahezi D FAU - Cabral, David A AU - Cabral DA CN - ARChiVe Investigators Network LA - eng PT - Journal Article PT - Validation Study DEP - 20120215 PL - Canada TA - J Rheumatol JT - The Journal of rheumatology JID - 7501984 RN - 0 (Antibodies, Antineutrophil Cytoplasmic) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Adult MH - Age Factors MH - Antibodies, Antineutrophil Cytoplasmic/*immunology MH - Blood Sedimentation MH - C-Reactive Protein/metabolism MH - Child MH - Cohort Studies MH - Female MH - Granulomatosis with Polyangiitis/diagnosis/immunology/physiopathology MH - Humans MH - Male MH - Pediatrics/standards MH - Registries/*standards MH - Reproducibility of Results MH - Retrospective Studies MH - Rheumatology/standards MH - *Severity of Illness Index MH - Vasculitis/*diagnosis/immunology/*physiopathology FIR - Sarmiento, Angelyne IR - Sarmiento A FIR - Espinosa, Victor IR - Espinosa V FIR - Houghton, Kristin IR - Houghton K FIR - Petty, Ross IR - Petty R FIR - Tucker, Lori IR - Tucker L FIR - Turvey, Stuart IR - Turvey S FIR - Brooks, Elizabeth B IR - Brooks EB FIR - Robinson, Angela IR - Robinson A FIR - Singer, Nora G IR - Singer NG FIR - Ilowite, Norman T IR - Ilowite NT FIR - Dedeoglu, Fatma IR - Dedeoglu F FIR - Fuhlbrigge, Robert IR - Fuhlbrigge R FIR - Hazen, Melissa IR - Hazen M FIR - Son, Mary Beth IR - Son MB FIR - Sundel, Robert IR - Sundel R FIR - Brown, Diane IR - Brown D FIR - Shaham, Bracha IR - Shaham B FIR - Adams, Matthew IR - Adams M FIR - Valentini, Rudolf IR - Valentini R FIR - Hirsh, Raphael IR - Hirsh R FIR - Kietz, Daniel IR - Kietz D FIR - Rosen, Paul IR - Rosen P FIR - Torok, Kathryn IR - Torok K FIR - Pachman, Lauren IR - Pachman L FIR - Brunner, Hermine IR - Brunner H FIR - Griffin, Thomas IR - Griffin T FIR - Grom, Alexi IR - Grom A FIR - Zeft, Andrew IR - Zeft A FIR - Hashkes, Phil IR - Hashkes P FIR - Eichenfield, Andrew IR - Eichenfield A FIR - Ardoin, Stacy IR - Ardoin S FIR - Schanberg, Laura IR - Schanberg L FIR - Laxer, Ronald IR - Laxer R FIR - Schneider, Rayfel IR - Schneider R FIR - Huber, Adam M IR - Huber AM FIR - Lang, Bianca A IR - Lang BA FIR - Stringer, Elizabeth IR - Stringer E FIR - Haines, Kathleen IR - Haines K FIR - Kimura, Yukiko IR - Kimura Y FIR - Weiss, Jennifer IR - Weiss J FIR - Lee, Tzielan IR - Lee T FIR - Balboni, Imelda IR - Balboni I FIR - Bromberg, Reuven IR - Bromberg R FIR - Cidon, Michal IR - Cidon M FIR - Frankovich, Jennifer IR - Frankovich J FIR - Gerstbacher, Dana IR - Gerstbacher D FIR - Hsu, Joyce J IR - Hsu JJ FIR - Park, Jane L IR - Park JL FIR - Sandborg, Christy IR - Sandborg C FIR - Song, Steven IR - Song S FIR - Reed, Ann IR - Reed A FIR - Magalnick, Michael IR - Magalnick M FIR - Ramirez, Andrea IR - Ramirez A FIR - Shishov, Michael IR - Shishov M FIR - Ballinger, Susan IR - Ballinger S FIR - Klausmeier, Thomas IR - Klausmeier T FIR - White, Andrew IR - White A FIR - Emery, Helen IR - Emery H FIR - Hayward, Kristin IR - Hayward K FIR - Ringold, Sarah IR - Ringold S FIR - Shaw, Elizabeth IR - Shaw E FIR - Turner, Jennifer IR - Turner J FIR - Wallace, Carol IR - Wallace C FIR - Myones, Barry L IR - Myones BL FIR - Cartwright, Victoria IR - Cartwright V FIR - Chedeville, Gaelle IR - Chedeville G FIR - Duffy, Ciaran IR - Duffy C FIR - Duffy, Karen IR - Duffy K FIR - Scuccimarri, Rosie IR - Scuccimarri R FIR - von Scheven, Emily IR - von Scheven E FIR - Jarvis, James IR - Jarvis J FIR - Punaro, Marilynn IR - Punaro M FIR - Pascual, Virginia IR - Pascual V FIR - Bonsack, John IR - Bonsack J FIR - Prahalad, Sampath IR - Prahalad S FIR - Abramson, Leslie IR - Abramson L EDAT- 2012/02/18 06:00 MHDA- 2013/02/05 06:00 CRDT- 2012/02/17 06:00 PHST- 2012/02/17 06:00 [entrez] PHST- 2012/02/18 06:00 [pubmed] PHST- 2013/02/05 06:00 [medline] AID - jrheum.111030 [pii] AID - 10.3899/jrheum.111030 [doi] PST - ppublish SO - J Rheumatol. 2012 May;39(5):1088-94. doi: 10.3899/jrheum.111030. Epub 2012 Feb 15.