PMID- 22339909
OWN - NLM
STAT- MEDLINE
DCOM- 20120521
LR  - 20120220
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 32
IP  - 11
DP  - 2011 Nov
TI  - [The type I insulin-like growth factor receptor highly expressed in clonal cells 
      of myelodysplastic syndromes].
PG  - 744-7
AB  - OBJECTIVE: To probe the expression level of insulin-like growth factor-I receptor 
      (IGF-IR) in malignant clone cells of myelodysplastic syndromes (MDS). METHOD: The 
      combination of fluorescence in situ hybridization (FISH) and immunochemistry 
      (alkaline phosphatase anti-alkaline phosphatase, APAAP) was used to detect the 
      expression of IGF-IR in the bone marrow cells of 40 MDS patients with abnormal 
      karyotypes. RESULTS: The average IGF-IR expression level on the clone cells 
      \[(84.5 +/- 14.2)%\] from the MDS cases was markedly elevated compared to the 
      corresponding level on normal cells \[(11.4 +/- 12.1)%\]. And the percentages of 
      malignant clone cells in all 40 MDS cases were significantly correlated with the 
      relevant percentages of IGF-IR positive nucleated cells (r = 0.929, P < 0.01). 
      CONCLUSIONS: IGF-IR might be taken as a marker of clone cells in MDS for its 
      trait to malignant proliferation.
FAU - He, Qi
AU  - He Q
AD  - The Department of Hematology, Shanghai Jiaotong University, Shanghai, China.
FAU - Li, Xiao
AU  - Li X
FAU - Zhang, Zheng
AU  - Zhang Z
FAU - Zhang, Qing-xia
AU  - Zhang QX
FAU - Yang, Lian-ping
AU  - Yang LP
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Clone Cells/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*metabolism/pathology
MH  - Receptor, IGF Type 1/*metabolism
MH  - Young Adult
EDAT- 2012/02/22 06:00
MHDA- 2012/05/23 06:00
CRDT- 2012/02/21 06:00
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2011 Nov;32(11):744-7.