PMID- 22341692
OWN - NLM
STAT- MEDLINE
DCOM- 20140224
LR  - 20161125
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 167
IP  - 2
DP  - 2013 Jul 31
TI  - Effect of autologous bone marrow mononuclear cells transplantation in diabetic 
      patients with ST-segment elevation myocardial infarction.
PG  - 537-47
LID - S0167-5273(12)00086-1 [pii]
LID - 10.1016/j.ijcard.2012.01.068 [doi]
AB  - BACKGROUND: To investigate the efficacy and proposed mechanism of bone marrow 
      mononuclear cells (BMMNCs) transplantation for diabetic and non-diabetic patients 
      with ST-segment elevation myocardial infarction (STEMI). METHODS: One hundred and 
      sixteen patients with STEMI who had successfully undergone percutaneous coronary 
      intervention (PCI) were divided into a diabetic group (n=51) and non-diabetic 
      group (n=65). All of the patients received intracoronary injection of BMMNCs. 
      RESULTS: Diabetes down-regulated IGF-1, IGFBP-5, VEGF, SDF-1, IL-6, IL-1alpha and 
      TNF-alpha expression and affected the expression of Bmi-1, Gfi1, Tel and Hox-B4 which 
      could prevent premature senescence and maintain the self-renewal capacity of stem 
      cells. Event-free survival rates were not statistically different between the 
      diabetic and non-diabetic group (80% vs. 72.5%, p=0.382). LV ejection fraction 
      (LVEF) and wall motion score index (WMSI) were evaluated by echocardiography and 
      found to be significantly improved in the non-diabetic group compared to the 
      diabetic group over the 4-year follow-up period. Improved myocardial perfusion 
      and reduced infarct size in the non-diabetic group compared to the diabetic group 
      was verified using single-photon emission computed tomographic (SPECT) imaging. 
      The non-diabetic group also had reduced anginal symptoms as assessed by changes 
      in their Seattle Angina Questionnaire scores and Canadian Cardiovascular Society 
      (CCS) Functional Angina classification. An improvement of 6-minute walk distance 
      (6MWD) was also noted to be higher in the non-diabetic group during the follow-up 
      period. CONCLUSION: This study indicates that the beneficial effect of BMMNCs 
      transplantation for STEMI is less pronounced in diabetic patients. The mechanism 
      is associated with decreased BMMNCs function in diabetic patients.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Sun, Dongdong
AU  - Sun D
AD  - Department of Cardiology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi, 710032, China.
FAU - Narsinh, Kazim
AU  - Narsinh K
FAU - Wang, Haichang
AU  - Wang H
FAU - Li, Chengxiang
AU  - Li C
FAU - Li, Weijie
AU  - Li W
FAU - Zhang, Zheng
AU  - Zhang Z
FAU - Li, Jiayi
AU  - Li J
FAU - Cao, Feng
AU  - Cao F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120216
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Adult
MH  - Bone Marrow Transplantation/*methods
MH  - Diabetes Mellitus/diagnostic imaging/*epidemiology/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnostic imaging/*epidemiology/*surgery
MH  - Radionuclide Imaging
MH  - Transplantation, Autologous
MH  - Treatment Outcome
EDAT- 2012/02/22 06:00
MHDA- 2014/02/25 06:00
CRDT- 2012/02/21 06:00
PHST- 2011/09/14 00:00 [received]
PHST- 2011/12/20 00:00 [revised]
PHST- 2012/01/22 00:00 [accepted]
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2014/02/25 06:00 [medline]
AID - S0167-5273(12)00086-1 [pii]
AID - 10.1016/j.ijcard.2012.01.068 [doi]
PST - ppublish
SO  - Int J Cardiol. 2013 Jul 31;167(2):537-47. doi: 10.1016/j.ijcard.2012.01.068. Epub 
      2012 Feb 16.