PMID- 22342872
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 73
IP  - 4
DP  - 2012 Apr
TI  - Estimation of human leukocyte antigen class I and class II high-resolution allele 
      and haplotype frequencies in the Italian population and comparison with other 
      European populations.
PG  - 399-404
LID - 10.1016/j.humimm.2012.01.005 [doi]
AB  - The high-resolution (HR) allele and haplotype frequencies of class I and II human 
      leukocyte antigen (HLA) system were determined in the Italian population from a 
      sample of donors recruited in the Italian Bone Marrow Donor Registry (IBMDR). 
      This study analyzed the HLA-A, -B, -C, -DRB1, and -DQB1 loci. Two different 
      samples were used: donors HR typed at least for one allele, usually when selected 
      for donor-recipient matching (respectively: 3596, 7591, 4715, 57345, and 8196), 
      to make a list of the observed alleles and determine the relative frequencies of 
      the alleles in each class of the corresponding antigen; donors HR randomly typed 
      for both the alleles (respectively: 975, 1643, 1569, 22114, and 2087) to estimate 
      the allele and haplotype frequencies, and two loci linkage disequilibrium. The 
      number of alleles showing a frequency >1% on the total number of observed alleles 
      are 18/75 HLA-A, 28/142 -B, 17/57 -C, 23/154 -DRB1, and 13/31 -DQB1. In each 
      locus they account for more than 88% of the total cumulative frequencies. The 
      most frequent alleles are A*02: 01, B*35: 01, C*04:01, DRB1*07:01, DQB1*03:01. 
      The most frequent five-locus haplotype in the 338 donors randomly typed is A*01: 
      01-C*07:01-B*08: 01-DRB1*03:01-DQB1*02:01. The genetic comparison of the Italian 
      population with 16 European populations shows a south-north gradient.
CI  - Copyright (c) 2012 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Rendine, Sabina
AU  - Rendine S
AD  - AOUSG Battista, Transplant Immunology Service, Torino, Italy.
FAU - Ferrero, Norma Maria
AU  - Ferrero NM
FAU - Sacchi, Nicoletta
AU  - Sacchi N
FAU - Costa, Cristina
AU  - Costa C
FAU - Pollichieni, Simona
AU  - Pollichieni S
FAU - Amoroso, Antonio
AU  - Amoroso A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120201
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - *Alleles
MH  - *Gene Frequency
MH  - *Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Italy/ethnology
MH  - Linkage Disequilibrium
MH  - White People/genetics
EDAT- 2012/02/22 06:00
MHDA- 2012/07/28 06:00
CRDT- 2012/02/21 06:00
PHST- 2011/08/02 00:00 [received]
PHST- 2011/12/22 00:00 [revised]
PHST- 2012/01/24 00:00 [accepted]
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - S0198-8859(12)00015-8 [pii]
AID - 10.1016/j.humimm.2012.01.005 [doi]
PST - ppublish
SO  - Hum Immunol. 2012 Apr;73(4):399-404. doi: 10.1016/j.humimm.2012.01.005. Epub 2012 
      Feb 1.