PMID- 22342914
OWN - NLM
STAT- MEDLINE
DCOM- 20120914
LR  - 20240104
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 514
IP  - 2
DP  - 2012 Apr 18
TI  - Hypoxia-inducible factor-1 and neuroglobin expression.
PG  - 137-40
LID - 10.1016/j.neulet.2012.01.080 [doi]
AB  - Neuroglobin (Ngb) is a hypoxia-inducible protein with cytoprotective effects in 
      animal models of stroke, Alzheimer's disease, and related disorders, but the 
      molecular mechanisms involved in its induction are unknown. We tested the 
      hypothesis that hypoxia-inducible factor-1 (HIF-1) regulates Ngb levels, using 
      shRNA-mediated knockdown and lentiviral vector-mediated overexpression of the 
      HIF-1alpha subunit, in cultured neural (HN33) cells. HIF-1alpha knockdown decreased and 
      HIF-1alpha overexpression increased Ngb levels, consistent with a connection between 
      HIF-1 and Ngb induction. These findings may have implications for understanding 
      the hypoxia-response repertoire of neural cells and devising therapeutic 
      strategies for neurologic disorders.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Haines, Bryan
AU  - Haines B
AD  - Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, 
      USA.
FAU - Demaria, Marco
AU  - Demaria M
FAU - Mao, Xiao
AU  - Mao X
FAU - Xie, Lin
AU  - Xie L
FAU - Campisi, Judith
AU  - Campisi J
FAU - Jin, Kunlin
AU  - Jin K
FAU - Greenberg, David A
AU  - Greenberg DA
LA  - eng
GR  - R01 NS062040/NS/NINDS NIH HHS/United States
GR  - R01 NS62040/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120210
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Hif1a protein, mouse)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuroglobin)
RN  - 0 (RNA, Small Interfering)
RN  - 9004-22-2 (Globins)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Cells, Cultured
MH  - Globins/genetics/*metabolism
MH  - Hippocampus/*metabolism
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism
MH  - Mice
MH  - Nerve Tissue Proteins/genetics/*metabolism
MH  - Neuroglobin
MH  - RNA, Small Interfering
PMC - PMC3526664
MID - NIHMS380675
EDAT- 2012/02/22 06:00
MHDA- 2012/09/15 06:00
PMCR- 2012/12/19
CRDT- 2012/02/21 06:00
PHST- 2011/12/16 00:00 [received]
PHST- 2012/01/27 00:00 [revised]
PHST- 2012/01/31 00:00 [accepted]
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/09/15 06:00 [medline]
PHST- 2012/12/19 00:00 [pmc-release]
AID - S0304-3940(12)00163-2 [pii]
AID - 10.1016/j.neulet.2012.01.080 [doi]
PST - ppublish
SO  - Neurosci Lett. 2012 Apr 18;514(2):137-40. doi: 10.1016/j.neulet.2012.01.080. Epub 
      2012 Feb 10.