PMID- 22343788
OWN - NLM
STAT- MEDLINE
DCOM- 20120828
LR  - 20161125
IS  - 1421-9824 (Electronic)
IS  - 1420-8008 (Linking)
VI  - 32
IP  - 6
DP  - 2011
TI  - Association between subcortical lesions and behavioral and psychological symptoms 
      in patients with Alzheimer's disease.
PG  - 417-23
LID - 10.1159/000335778 [doi]
AB  - BACKGROUND/AIMS: The most devastating features of Alz-heimer's disease (AD) are 
      often the behavioral and psychological symptoms in dementia (BPSD). There is 
      controversy as to whether subcortical lesions contribute to BPSD. The aim of this 
      study was to examine the relationship between BPSD and subcortical lesions 
      (white-matter lesions and lacunes) in AD. METHODS: CT or MRI from 259 patients 
      with mild-to-moderate AD were assessed with the Age-Related White Matter Changes 
      scale. Linear measures of global and temporal atrophy and Mini-Mental State 
      Examination scores were used to adjust for AD pathology and disease severity in 
      logistic regression models with the BPSD items delusions, hallucinations, 
      agitation, depression, anxiety, apathy and irritability. RESULTS: Lacunes in the 
      left basal ganglia were associated with delusions (OR 2.57, 95% CI 1.21-5.48) and 
      hallucinations (OR 3.33, 95% CI 1.38-8.01) and lacunes in the right basal ganglia 
      were associated with depression (OR 2.13, 95% CI 1.01-4.51). CONCLUSION: Lacunes 
      in the basal ganglia resulted in a 2- to 3-fold increased risk of delusions, 
      hallucinations and depression, when adjusting for cognition and atrophy. This 
      suggests that basal ganglia lesions can contribute to BPSD in patients with AD, 
      independently of the AD process.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Palmqvist, Sebastian
AU  - Palmqvist S
AD  - Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, 
      Malmo, Sweden. sebastian.palmqvist@med.lu.se
FAU - Sarwari, Agmall
AU  - Sarwari A
FAU - Wattmo, Carina
AU  - Wattmo C
FAU - Bronge, Lena
AU  - Bronge L
FAU - Zhang, Yi
AU  - Zhang Y
FAU - Wahlund, Lars Olof
AU  - Wahlund LO
FAU - Nagga, Katarina
AU  - Nagga K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120216
PL  - Switzerland
TA  - Dement Geriatr Cogn Disord
JT  - Dementia and geriatric cognitive disorders
JID - 9705200
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*complications/diagnostic imaging/pathology/psychology
MH  - Basal Ganglia/pathology
MH  - Basal Ganglia Diseases/complications/pathology/*psychology
MH  - Behavioral Symptoms
MH  - Delusions/*complications/pathology
MH  - Depression/*complications/pathology
MH  - Female
MH  - Frontal Lobe/pathology
MH  - Hallucinations/*complications/pathology
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Parietal Lobe/pathology
MH  - Radiography
EDAT- 2012/02/22 06:00
MHDA- 2012/08/29 06:00
CRDT- 2012/02/21 06:00
PHST- 2011/12/12 00:00 [accepted]
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/08/29 06:00 [medline]
AID - 000335778 [pii]
AID - 10.1159/000335778 [doi]
PST - ppublish
SO  - Dement Geriatr Cogn Disord. 2011;32(6):417-23. doi: 10.1159/000335778. Epub 2012 
      Feb 16.