PMID- 22343919
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20220408
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 119
IP  - 14
DP  - 2012 Apr 5
TI  - Natural killer cell degranulation capacity predicts early onset of the immune 
      reconstitution inflammatory syndrome (IRIS) in HIV-infected patients with 
      tuberculosis.
PG  - 3315-20
LID - 10.1182/blood-2011-09-377523 [doi]
AB  - Immune reconstitution inflammatory syndrome (IRIS) is a common and potentially 
      serious complication occurring in HIV-infected patients being treated for 
      tuberculosis (TB) using combined antiretroviral treatment. A role of adaptive 
      immunity has been suggested in the onset of IRIS, whereas the role of natural 
      killer (NK) cells has not yet been explored. The present study sought to examine 
      the involvement of NK cells in the onset of IRIS in HIV-infected patients with TB 
      and to identify predictive markers of IRIS. A total of 128 HIV-infected patients 
      with TB from the Cambodian Early versus Late Introduction of Antiretroviral Drugs 
      (CAMELIA) trial were enrolled in Cambodia. Thirty-seven of the 128 patients 
      developed IRIS. At inclusion, patients had low CD4 cell counts (27 cells/mm(3)) 
      and high plasma viral load (5.76 and 5.50 log/mL in IRIS and non-IRIS patients, 
      respectively). At baseline, NK-cell degranulation capacity was significantly 
      higher in IRIS patients than in non-IRIS patients (9.6% vs 6.38%, P < .005). At 
      IRIS onset, degranulation capacity did not differ between patients, whereas 
      activating receptor expression was lower in IRIS patients. Patients with 
      degranulation levels > 10.84% had a higher risk of IRIS (P = .002 by log-rank 
      test). Degranulation level at baseline was the most important IRIS predictor 
      (hazard ratio = 4.41; 95% confidence interval, 1.60-12.16). We conclude that 
      NK-degranulation levels identify higher IRIS risk in HIV-infected patients with 
      TB.
FAU - Pean, Polidy
AU  - Pean P
AD  - Institut Pasteur in Cambodia, Phnom Penh, Cambodia.
FAU - Nerrienet, Eric
AU  - Nerrienet E
FAU - Madec, Yoann
AU  - Madec Y
FAU - Borand, Laurence
AU  - Borand L
FAU - Laureillard, Didier
AU  - Laureillard D
FAU - Fernandez, Marcelo
AU  - Fernandez M
FAU - Marcy, Olivier
AU  - Marcy O
FAU - Sarin, Chan
AU  - Sarin C
FAU - Phon, Kerya
AU  - Phon K
FAU - Taylor, Sylvia
AU  - Taylor S
FAU - Pancino, Gianfranco
AU  - Pancino G
FAU - Barre-Sinoussi, Francoise
AU  - Barre-Sinoussi F
FAU - Scott-Algara, Daniel
AU  - Scott-Algara D
CN  - Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA) study 
      team
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120217
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD69 antigen)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Natural Killer Cell)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Antigens, CD/metabolism
MH  - Antigens, Differentiation, T-Lymphocyte/metabolism
MH  - Antiretroviral Therapy, Highly Active
MH  - Cell Degranulation/*immunology
MH  - Coinfection/immunology
MH  - Female
MH  - HIV Infections/complications/drug therapy/*immunology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/complications/*immunology
MH  - Interferon-gamma/metabolism
MH  - Killer Cells, Natural/*immunology/metabolism
MH  - Lectins, C-Type/metabolism
MH  - Male
MH  - Receptors, Natural Killer Cell/metabolism
MH  - Tuberculosis/complications/*immunology
FIR - Sok, Thim
IR  - Sok T
FIR - Blanc, Francois-Xavier
IR  - Blanc FX
FIR - Goldfeld, Anne E
IR  - Goldfeld AE
FIR - Laureillard, Didier
IR  - Laureillard D
FIR - Rekacewitz, Claire
IR  - Rekacewitz C
FIR - Vong, Sirenda
IR  - Vong S
EDAT- 2012/02/22 06:00
MHDA- 2012/06/20 06:00
CRDT- 2012/02/21 06:00
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - S0006-4971(20)48031-0 [pii]
AID - 10.1182/blood-2011-09-377523 [doi]
PST - ppublish
SO  - Blood. 2012 Apr 5;119(14):3315-20. doi: 10.1182/blood-2011-09-377523. Epub 2012 
      Feb 17.