PMID- 22344183
OWN - NLM
STAT- MEDLINE
DCOM- 20120912
LR  - 20120629
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 147
IP  - 1
DP  - 2012 Jul
TI  - Head and neck manifestations of the immune reconstitution syndrome in 
      HIV-infected patients: a cohort study.
PG  - 52-6
LID - 10.1177/0194599812437321 [doi]
AB  - OBJECTIVE: To describe head and neck manifestations of immune reconstitution 
      inflammatory syndrome (IRIS) in a cohort of HIV-infected patients receiving 
      combined antiretroviral therapy (cART). After initiation of cART, some 
      HIV-infected patients present a paradoxical worsening and clinical deterioration 
      due to pathological inflammatory reactions to infectious or noninfectious 
      antigens, a condition known as IRIS. STUDY DESIGN: Prospective study with a 
      follow-up period of 6 to 24 months. SETTING: Tertiary referral center in Mexico 
      City. METHODS: Our cohort was integrated by 165 patients who had started cART 
      within the past 2 months prior to study entry. Patients underwent a complete ear, 
      nose, and throat examination (ENT). Laboratory tests (hematology and blood 
      chemistry), cultures from body fluids, and biopsies were performed. RESULTS: Of 
      the 165 patients studied, 21 (12.7%) presented IRIS in the head and neck region. 
      Kaposi sarcoma was the most common presentation, observed in 7 patients. 
      Tuberculosis-associated IRIS was observed in 6 patients with scrophulas, lymph 
      node enlargement, or retropharyngeal abscess. Other manifestations included 
      herpes simplex I infection and unilateral vocal fold palsy secondary to 
      Mycobacterium avium intracelulare paratracheal abscess and scrophulas, as well as 
      cervical lymph node histoplasmosis and facial palsy. CONCLUSIONS: To our 
      knowledge, this is the first prospective study describing the different 
      manifestations of IRIS in the head and neck region.
FAU - Ablanedo-Terrazas, Yuria
AU  - Ablanedo-Terrazas Y
AD  - Centro de Investigacion en Enfermedades Infecciosas, Instituto Nacional de 
      Enfermedades Respiratorias, Mexico City, Mexico.
FAU - Alvarado-de la Barrera, Claudia
AU  - Alvarado-de la Barrera C
FAU - Ormsby, Christopher E
AU  - Ormsby CE
FAU - Reyes-Teran, Gustavo
AU  - Reyes-Teran G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120215
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - HIV Infections/*complications
MH  - Head and Neck Neoplasms/*etiology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*complications
MH  - Male
MH  - Otorhinolaryngologic Diseases/*etiology
MH  - Prospective Studies
MH  - Sarcoma, Kaposi/*etiology
MH  - Tuberculosis/*etiology
EDAT- 2012/02/22 06:00
MHDA- 2012/09/13 06:00
CRDT- 2012/02/21 06:00
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/09/13 06:00 [medline]
AID - 0194599812437321 [pii]
AID - 10.1177/0194599812437321 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2012 Jul;147(1):52-6. doi: 10.1177/0194599812437321. 
      Epub 2012 Feb 15.