PMID- 22344545
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20211203
IS  - 1099-0801 (Electronic)
IS  - 0269-3879 (Linking)
VI  - 26
IP  - 12
DP  - 2012 Dec
TI  - Development and validation of automated SPE-HPLC-MS/MS methods for the 
      quantification of asenapine, a new antipsychotic agent, and its two major 
      metabolites in human urine.
PG  - 1461-3
LID - 10.1002/bmc.2722 [doi]
AB  - To support the evaluation of the pharmacokinetic parameters of asenapine (ASE) in 
      urine, we developed and validated online solid-phase extraction high-performance 
      liquid chromatography methods with tandem mass spectrometry detection 
      (SPE-LC-MS/MS) for the quantification of ASE and two of its major metabolites, 
      N-desmethylasenapine (DMA) and asenapine-N(+)-glucuronide (ASG). The linearity in 
      human urine was found acceptable for quantification in a concentration range of 
      0.500-100 ng/mL for ASE and DMA and 10.0-3000 ng/mL for ASG, respectively.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - de Boer, Theo
AU  - de Boer T
AD  - QPS Netherlands, Petrus Campersingel 123, 9713, AG, Groningen, The Netherlands. 
      theo.de.boer@qps.com
FAU - Meulman, Erik
AU  - Meulman E
FAU - Meijering, Henri
AU  - Meijering H
FAU - Wieling, Jaap
AU  - Wieling J
FAU - Dogterom, Peter
AU  - Dogterom P
FAU - Lass, Holger
AU  - Lass H
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120216
PL  - England
TA  - Biomed Chromatogr
JT  - Biomedical chromatography : BMC
JID - 8610241
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Dibenzocycloheptenes)
RN  - 0 (Heterocyclic Compounds, 4 or More Rings)
RN  - JKZ19V908O (asenapine)
SB  - IM
MH  - Antipsychotic Agents/pharmacokinetics/*urine
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Dibenzocycloheptenes
MH  - Double-Blind Method
MH  - Heterocyclic Compounds, 4 or More Rings/pharmacokinetics/*urine
MH  - Humans
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Solid Phase Extraction/*methods
MH  - Tandem Mass Spectrometry/*methods
EDAT- 2012/02/22 06:00
MHDA- 2013/02/27 06:00
CRDT- 2012/02/21 06:00
PHST- 2011/03/21 00:00 [received]
PHST- 2012/01/11 00:00 [revised]
PHST- 2012/01/11 00:00 [accepted]
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
AID - 10.1002/bmc.2722 [doi]
PST - ppublish
SO  - Biomed Chromatogr. 2012 Dec;26(12):1461-3. doi: 10.1002/bmc.2722. Epub 2012 Feb 
      16.