PMID- 2234508
OWN - NLM
STAT- MEDLINE
DCOM- 19901212
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 115
IP  - 2-3
DP  - 1990 Jul 31
TI  - Inhibitory influences of mammalian FMRFamide (Phe-Met-Arg-Phe-amide)-related 
      peptides on nociception and morphine- and stress-induced analgesia in mice.
PG  - 307-12
AB  - The effects of two endogenous mammalian FMRFamide (Phe-Met-Arg-Phe-NH2)-related 
      peptides, an octapeptide F8Fa (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2) and an 
      octadecapeptide A18Fa 
      (Ala-Gly-Glu-Gly-Leu-Ser-Ser-Pro-Phe-Trp-Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe -NH2) on 
      morphine- and restraint stress-induced analgesia and basal nociceptive 
      sensitivity, as measured by the latency of a foot-lifting response to a warmed 
      surface, were examined in male mice. Intracerebroventricular (i.c.v.) 
      administrations of F8Fa and A18Fa (0.10-10 micrograms) during the day-time 
      significantly reduced morphine (10 mg/kg) and restraint-induced analgesia at 30 
      min after administration, with F8Fa having a greater inhibitory effect than 
      A18Fa. At night during the dark period i.c.v. F8Fa also significantly reduced the 
      elevated nocturnal thermal response latency, while not affecting the shorter 
      day-time nociceptive responses. Peripheral administrations of the prototypic 
      opiate antagonist, naloxone (1.0 mg/kg), had similar inhibitory effects on 
      morphine- and stress-induced analgesia, and the day-night rhythm of nociceptive 
      sensitivity. These results indicate that F8Fa and A18Fa are involved in the 
      modulation of opioid analgesia and suggest that these endogenous 
      FMRFamide-related peptides may be associated with the expression of the day-night 
      rhythm of opioid-mediated nociceptive sensitivity.
FAU - Kavaliers, M
AU  - Kavaliers M
AD  - Division of Oral Biology, Faculty of Denistry, University of Western Ontario, 
      London, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Endorphins)
RN  - 0 (Neuropeptides)
RN  - 0 (Oligopeptides)
RN  - 64190-70-1 (FMRFamide)
RN  - 76I7G6D29C (Morphine)
RN  - 99566-27-5 
      (phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide)
RN  - 99588-52-0 (A18Famide)
SB  - IM
MH  - Amino Acid Sequence
MH  - *Analgesia
MH  - Animals
MH  - Circadian Rhythm/physiology
MH  - Endorphins/*physiology
MH  - FMRFamide
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Morphine/*pharmacology
MH  - Neuropeptides/*physiology
MH  - Oligopeptides/*pharmacology/physiology
MH  - Pain/*metabolism/physiopathology
MH  - Restraint, Physical
MH  - Stress, Psychological/*metabolism/physiopathology
OID - NASA: 91043764
EDAT- 1990/07/31 00:00
MHDA- 1990/07/31 00:01
CRDT- 1990/07/31 00:00
PHST- 1990/07/31 00:00 [pubmed]
PHST- 1990/07/31 00:01 [medline]
PHST- 1990/07/31 00:00 [entrez]
AID - 0304-3940(90)90473-M [pii]
AID - 10.1016/0304-3940(90)90473-m [doi]
PST - ppublish
SO  - Neurosci Lett. 1990 Jul 31;115(2-3):307-12. doi: 10.1016/0304-3940(90)90473-m.