PMID- 22345339
OWN - NLM
STAT- MEDLINE
DCOM- 20120717
LR  - 20190919
IS  - 1665-2681 (Print)
IS  - 1665-2681 (Linking)
VI  - 11
IP  - 2
DP  - 2012 Mar-Apr
TI  - Liver transplantation for autoimmune hepatitis in Peru: outcomes and recurrence.
PG  - 222-7
AB  - BACKGROUND: Liver transplantation is the only therapy for end-stage liver 
      disease. Cirrhosis secondary to autoimmune hepatitis (AIH) is an indication in 
      4-6% of adult transplants. AIMS: To describe the outcomes and recurrence of AIH 
      in liver transplant patients. MATERIAL AND METHODS: Twenty patients were 
      retrospectively studied. RESULTS: The female/male ratio was 3:1, the median age 
      was 36.7 years (range, 16 to 39 years), and the median MELD score was 18.5. 
      According to serological analysis, 19 patients were AIH type 1 and one patient 
      was AIH type 2. AIH was associated with human leukocyte antigen (HLA) DR13+ and 
      DR4+. The overall 5-year patient and graft survival rates were 94 and 85%, 
      respectively. Three (15.7%) cases of recurrent AIH were diagnosed based on 
      histological evidence. Clinical and histological features of acute and chronic 
      rejection were present in four (20%) and three (16.6%) patients, respectively. 
      CONCLUSION: AIH frequently affected young women, was the most frequent indication 
      for liver transplantation. Rejection and recurrence were commonly associated with 
      AIH, but did not affect patient survival. No significant relationship between 
      HLA-DR type and recurrence was found. Rapid progression to cirrhosis should be 
      considered in severe recurrences.
FAU - Padilla, Martin
AU  - Padilla M
AD  - Transplant Department, Guillermo Almenara I. National Hospital, ESSALUD, Lima, 
      Peru. pedro.padilla@essalud.gob.pe
FAU - Mayorga, Rosario
AU  - Mayorga R
FAU - Carrasco, Felix
AU  - Carrasco F
FAU - Bedregal, Tayana
AU  - Bedregal T
FAU - Bobadilla, Fernando
AU  - Bobadilla F
FAU - Rondon, Carlos
AU  - Rondon C
FAU - Chaman, Jose
AU  - Chaman J
LA  - eng
PT  - Journal Article
PL  - Mexico
TA  - Ann Hepatol
JT  - Annals of hepatology
JID - 101155885
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Disease-Free Survival
MH  - Female
MH  - Graft Rejection
MH  - Graft Survival
MH  - HLA-DR Serological Subtypes/*immunology
MH  - HLA-DR4 Antigen/*immunology
MH  - Hepatitis, Autoimmune/complications/immunology/*surgery
MH  - Humans
MH  - Liver Cirrhosis/etiology/*surgery
MH  - *Liver Transplantation
MH  - Male
MH  - Middle Aged
MH  - Peru
MH  - Recurrence
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2012/02/22 06:00
MHDA- 2012/07/18 06:00
CRDT- 2012/02/21 06:00
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/07/18 06:00 [medline]
AID - S1665-2681(19)31027-0 [pii]
PST - ppublish
SO  - Ann Hepatol. 2012 Mar-Apr;11(2):222-7.