PMID- 22345769
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1998-3611 (Electronic)
IS  - 0019-5154 (Print)
IS  - 0019-5154 (Linking)
VI  - 56
IP  - 6
DP  - 2011 Nov
TI  - STUDY OF THE ROLE OF SERUM FOLIC ACID IN ATOPIC DERMATITIS: A CORRELATION WITH 
      SERUM IgE AND DISEASE SEVERITY.
PG  - 673-7
LID - 10.4103/0019-5154.91827 [doi]
AB  - BACKGROUND: Most atopic dermatitis (AD) patients have elevated serum 
      immunoglobulin E (IgE). Impaired folic acid (FA) metabolism was found to reduce 
      the intracellular methyl donor pool, associated with a higher prevalence of 
      atopy. AIM: To assess serum IgE and FA in AD patients and to correlate their 
      levels with the disease severity, and with each other. MATERIALS AND METHODS: 
      Twenty patients with AD were assessed for serum FA and IgE, compared with 20 age- 
      and sex-matched controls. Patients were classified into three groups (mild, 
      moderate, and severe AD) based on clinical severity according to Nottingham 
      index. In both patients and controls, serum IgE was measured using Enzyme-linked 
      immunosorbent assay technique and serum FA was measured using Microparticle 
      Enzyme Immunoassay technique. RESULTS: Serum FA levels were lower in AD patients 
      compared with controls, but the difference was not statistically significant. FA 
      levels did not show statistically significant difference among disease severity 
      groups and did not correlate with serum IgE levels. On the other hand, serum IgE 
      levels were significantly elevated in AD patients compared with controls, and 
      among AD patients, its levels were significantly elevated in severe AD compared 
      with mild and moderate disease. CONCLUSION: Serum IgE is useful in assessment of 
      AD severity and activity. FA contribution to AD needs further investigations.
FAU - Shaheen, Maha A
AU  - Shaheen MA
AD  - Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Ain 
      Shams University, Cairo, Egypt .
FAU - Attia, Enas A S
AU  - Attia EA
FAU - Louka, Manal L
AU  - Louka ML
FAU - Bareedy, Nashwa
AU  - Bareedy N
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Dermatol
JT  - Indian journal of dermatology
JID - 0370750
PMC - PMC3276895
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - IgE
OT  - folic acid
COIS- Conflict of Interest: Nil.
EDAT- 2012/02/22 06:00
MHDA- 2012/02/22 06:01
PMCR- 2011/11/01
CRDT- 2012/02/21 06:00
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/02/22 06:01 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - IJD-56-673 [pii]
AID - 10.4103/0019-5154.91827 [doi]
PST - ppublish
SO  - Indian J Dermatol. 2011 Nov;56(6):673-7. doi: 10.4103/0019-5154.91827.