PMID- 22345789
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1998-3611 (Electronic)
IS  - 0019-5154 (Print)
IS  - 0019-5154 (Linking)
VI  - 56
IP  - 6
DP  - 2011 Nov
TI  - Disseminated granuloma annulare: a cutaneous adverse effect of anti-tnf agents.
PG  - 752-4
LID - 10.4103/0019-5154.91847 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) inhibitors, such as etanercept, infliximab, 
      and adalimumab, bind to TNF-alpha and thereby act as anti-inflammatory agents. This 
      group of drugs has been approved for the treatment of rheumatoid arthritis, 
      psoriatic arthritis, moderate to severe plaque psoriasis, ankylosing spodylitis, 
      Crohn disease, and juvenile idiopathic arthritis. We describe a 56-year-old woman 
      who developed an erythematous pruritic rash on both arms-diagnosed as granuloma 
      annulare by skin biopsy-approximately 22 months after initiating adalimumab for 
      treatment of rheumatoid arthritis. On stopping adalimumab there was total 
      clearance of the skin lesions, but a similar rash developed again when her 
      treatment was switched to another anti-TNF agent (etanercept). This clinical 
      observation supports a link between TNF inhibition and the development of 
      granuloma annulare.
FAU - Ratnarathorn, Mondhipa
AU  - Ratnarathorn M
AD  - School of Medicine, University of California Davis, Davis, CA, Department of 
      Dermatology and Division of Rheumatology, Allergy and Clinical Immunology, VA 
      Sacramento Medical Center, Sacramento, CA, USA .
FAU - Raychaudhuri, Siba P
AU  - Raychaudhuri SP
FAU - Naguwa, Stanley
AU  - Naguwa S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Dermatol
JT  - Indian journal of dermatology
JID - 0370750
PMC - PMC3276915
OTO - NOTNLM
OT  - Adverse effect
OT  - anti-TNF therapy
OT  - granuloma annulare
COIS- Conflict of Interest: Nil.
EDAT- 2012/02/22 06:00
MHDA- 2012/02/22 06:01
PMCR- 2011/11/01
CRDT- 2012/02/21 06:00
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/02/22 06:01 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - IJD-56-752 [pii]
AID - 10.4103/0019-5154.91847 [doi]
PST - ppublish
SO  - Indian J Dermatol. 2011 Nov;56(6):752-4. doi: 10.4103/0019-5154.91847.