PMID- 22346082
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1998-4766 (Electronic)
IS  - 0974-1208 (Print)
IS  - 1998-4766 (Linking)
VI  - 4
IP  - 3
DP  - 2011 Sep
TI  - Role of 14-bp deletion/insertion polymorphism in exon 8 of the HLA-G gene in 
      recurrent spontaneous abortion patients.
PG  - 143-6
LID - 10.4103/0974-1208.92289 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA)-G belongs to the nonclassical Class I 
      major histocompatibility complex, and is predominantly and specifically found on 
      the extravillous cytotrophoblast cells of the placenta. HLA-G has been postulated 
      as an important immunotolerant molecule in maintaining successful pregnancy and 
      maternal tolerance of the semiallogenic fetus. Recent reports indicate that the 
      14-bp deletion/insertion polymorphism in exon 8 of the 3'UTR region of the HLA-G 
      gene influences the HLA-G mRNA stability and isoform splicing patterns, thus 
      modulating the levels of HLA-G expression. AIM: The aim was to study the 14-bp 
      deletion/insertion polymorphism in exon 8 of the 3'UTR region of the HLA-G gene. 
      MATERIALS AND METHODS: A total of 50 women with unexplained three or more 
      recurrent spontaneous abortions (RSAs) and 41 normal healthy control women who 
      have had normal pregnancies and were genotyped for the 14-bp deletion/insertion 
      polymorphism were genotyped for the 14-bp deletion/insertion polymorphism by 
      polymerase chain reaction for exon 8-specific primers RESULTS: It was found that 
      the 14-bp allele deletion frequency was lower in patients (67%) versus controls 
      (73%), while 14-bp allele insertion was higher among patients (33%) versus 
      controls (9%). Similarly, the homozygous deletion halotype was higher among the 
      controls (80.48%); the heterozygous insertion deletion haplotype (34%) and 
      homozygous insertion haplotype (16%) were higher in RSA patients. The HLA 
      haplotype HLA A*02:11_B*40:06:01:01 was increased among RSA women compared to 
      controls. CONCLUSION: Our results suggest that 14-bp deletion/insertion 
      polymorphisms might have importance in the outcome of pregnancy and the 14-bp 
      deletion polymorphism in exon 8 of the HLA-G gene may be important from an 
      evolutionary perspective of successful pregnancy.
FAU - Shankarkumar, U
AU  - Shankarkumar U
AD  - Department of HLA and Transplantation, National Institute of Immunohaematology, 
      KEM Hospital Campus, Parel, Mumbai, India.
FAU - Shankarkumar, A
AU  - Shankarkumar A
FAU - Chedda, Z
AU  - Chedda Z
FAU - Ghosh, K
AU  - Ghosh K
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Hum Reprod Sci
JT  - Journal of human reproductive sciences
JID - 101473512
PMC - PMC3276949
OTO - NOTNLM
OT  - HLA-G 14-bp deletion/insertion gene
OT  - India
OT  - RSA
COIS- Conflict of Interest: None declared.
EDAT- 2012/02/22 06:00
MHDA- 2012/02/22 06:01
PMCR- 2011/09/01
CRDT- 2012/02/21 06:00
PHST- 2011/03/06 00:00 [received]
PHST- 2011/06/04 00:00 [revised]
PHST- 2011/09/21 00:00 [accepted]
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/02/22 06:01 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - JHRS-4-143 [pii]
AID - 10.4103/0974-1208.92289 [doi]
PST - ppublish
SO  - J Hum Reprod Sci. 2011 Sep;4(3):143-6. doi: 10.4103/0974-1208.92289.