PMID- 22346448
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1180-2332 (Print)
IS  - 1180-2332 (Linking)
VI  - 4
IP  - 4
DP  - 1993 Jul
TI  - Human herpesvirus 6 and chronic fatigue syndrome.
PG  - 199-202
AB  - The cause of chronic fatigue syndrome (CFS) is still enigmatic. Using indirect 
      immunofluorescence testing for measuring antibody against human herpesvirus 6 
      (HHV-6), this study investigated the association of CFS with infection by HHV-6. 
      Seventeen patients (group A) fulfilling the Centers for Disease Control (CDC) 
      definition for CFS were compared with eight patients (group B) with chronic 
      fatigue but not meeting the CDC criteria. No significant difference was found 
      between the two groups for 30 parameters including sex, age, exposure to children 
      and serology for Epstein-Barr virus, cytomegalovirus, herpes simplex virus, and 
      toxoplasma. Univariate analysis showed that patients in group A complained more 
      frequently of a sore throat, headache and of recurrent type of fatigue. These 
      three parameters are discriminant in identifying patients who will meet the CDC 
      case definition of CFS. The titre of antibody against HHV-6 in group A (1:99) was 
      significantly higher than in group B (1:15) (P=0.007). Elevated HHV-6 titres 
      suggests that this virus could be a cofactor in the pathogenesis of CFS.
FAU - Eymard, D
AU  - Eymard D
AD  - Department of Microbiology and Division of Infectious Diseases, Montreal General 
      Hospital, McGill University, Montreal, Quebec.
FAU - Lebel, F
AU  - Lebel F
FAU - Miller, M
AU  - Miller M
FAU - Turgeon, F
AU  - Turgeon F
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can J Infect Dis
JT  - The Canadian journal of infectious diseases = Journal canadien des maladies 
      infectieuses
JID - 9425856
PMC - PMC3250792
OTO - NOTNLM
OT  - Chronic fatigue syndrome
OT  - Human herpesvirus 6
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
PMCR- 1994/07/01
CRDT- 2012/02/21 06:00
PHST- 1992/07/13 00:00 [received]
PHST- 1992/11/20 00:00 [accepted]
PHST- 2012/02/21 06:00 [entrez]
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [pmc-release]
AID - idmm04199 [pii]
AID - 10.1155/1993/414602 [doi]
PST - ppublish
SO  - Can J Infect Dis. 1993 Jul;4(4):199-202. doi: 10.1155/1993/414602.