PMID- 22346771
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2092-6685 (Electronic)
IS  - 1598-2629 (Print)
IS  - 1598-2629 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Dec
TI  - HLA and Disease Associations in Koreans.
PG  - 324-35
LID - 10.4110/in.2011.11.6.324 [doi]
AB  - The human leukocyte antigen (HLA), the major histocompatibility complex (MHC) in 
      humans has been known to reside on chromosome 6 and encodes cell-surface 
      antigen-presenting proteins and many other proteins related to immune system 
      function. The HLA is highly polymorphic and the most genetically variable coding 
      loci in humans. In addition to a critical role in transplantation medicine, HLA 
      and disease associations have been widely studied across the populations 
      world-wide and are found to be important in prediction of disease susceptibility, 
      resistance and of evolutionary maintenance of genetic diversity. Because recently 
      developed molecular based HLA typing has several advantages like improved 
      specimen stability and increased resolution of HLA types, the association between 
      HLA alleles and a given disease could be more accurately quantified. Here, in 
      this review, we have collected HLA association data on some autoimmune diseases, 
      infectious diseases, cancers, drug responsiveness and other diseases with unknown 
      etiology in Koreans and attempt to summarize some remarkable HLA alleles related 
      with specific diseases.
FAU - Ahn, Stephen
AU  - Ahn S
AD  - Department of Microbiology and Immunology, College of Medicine, The Catholic 
      University of Korea, Seoul 137-701, Korea.
FAU - Choi, Hee-Back
AU  - Choi HB
FAU - Kim, Tai-Gyu
AU  - Kim TG
LA  - eng
PT  - Journal Article
DEP - 20111231
PL  - Korea (South)
TA  - Immune Netw
JT  - Immune network
JID - 101137270
PMC - PMC3275700
OTO - NOTNLM
OT  - Disease association
OT  - HLA
OT  - Korean
COIS- The author have no financial conflict of interest.
EDAT- 2012/02/22 06:00
MHDA- 2012/02/22 06:01
PMCR- 2011/12/01
CRDT- 2012/02/21 06:00
PHST- 2011/10/01 00:00 [received]
PHST- 2011/10/13 00:00 [revised]
PHST- 2011/10/19 00:00 [accepted]
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/02/22 06:01 [medline]
PHST- 2011/12/01 00:00 [pmc-release]
AID - 10.4110/in.2011.11.6.324 [doi]
PST - ppublish
SO  - Immune Netw. 2011 Dec;11(6):324-35. doi: 10.4110/in.2011.11.6.324. Epub 2011 Dec 
      31.