PMID- 22346781
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2092-6685 (Electronic)
IS  - 1598-2629 (Print)
IS  - 1598-2629 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Dec
TI  - Maturation-resistant dendritic cells ameliorate experimental autoimmune 
      uveoretinitis.
PG  - 399-405
LID - 10.4110/in.2011.11.6.399 [doi]
AB  - BACKGROUND: Endogenous uveitis is a chronic inflammatory eye disease of human, 
      which frequently leads to blindness. Experimental autoimmune uveoretinitis (EAU) 
      is an animal disease model of human endogenous uveitis and can be induced in 
      susceptible animals by immunization with retinal antigens. EAU resembles the key 
      immunological characteristics of human disease in that both are CD4(+) T-cell 
      mediated diseases. Dendritic cells (DCs) are specialized antigen-presenting cells 
      that are uniquely capable of activating naive T cells. Regulation of immune 
      responses through modulation of DCs has thus been tried extensively. Recently our 
      group reported that donor strain-derived immature DC pretreatment successfully 
      controlled the adverse immune response during allogeneic transplantation. 
      METHODS: EAU was induced by immunization with human interphotoreceptor 
      retinoid-binding protein (IRBP) peptide(1-20). Dendritic cells were 
      differentiated from bone marrow in the presence of recombinant GM-CSF. RESULTS: 
      In this study, we used paraformaldehyde-fixed bone marrow-derived DCs to maintain 
      them in an immature state. Pretreatment with fixed immature DCs, but not fixed 
      mature DCs, ameliorated the disease progression of EAU by inhibiting uveitogenic 
      CD4(+) T cell activation and differentiation. CONCLUSION: Application of iBMDC 
      prepared according to the protocol of this study would provide an important 
      treatment modality for the autoimmune diseases and transplantation rejection.
FAU - Oh, Keunhee
AU  - Oh K
AD  - Laboratory of Immunology, Transplantation Research Institute, Seoul National 
      University College of Medicine, Seoul 110-799, Korea.
FAU - Kim, Yon Su
AU  - Kim YS
FAU - Lee, Dong-Sup
AU  - Lee DS
LA  - eng
PT  - Journal Article
DEP - 20111231
PL  - Korea (South)
TA  - Immune Netw
JT  - Immune network
JID - 101137270
PMC - PMC3275710
OTO - NOTNLM
OT  - Dendritic cells
OT  - Experimental Autoimmune Uveoretinitis (EAU)
OT  - Maturation
COIS- The authors have no financial conflict of interest.
EDAT- 2012/02/22 06:00
MHDA- 2012/02/22 06:01
PMCR- 2011/12/01
CRDT- 2012/02/21 06:00
PHST- 2011/10/17 00:00 [received]
PHST- 2011/11/07 00:00 [revised]
PHST- 2011/11/11 00:00 [accepted]
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/02/22 06:01 [medline]
PHST- 2011/12/01 00:00 [pmc-release]
AID - 10.4110/in.2011.11.6.399 [doi]
PST - ppublish
SO  - Immune Netw. 2011 Dec;11(6):399-405. doi: 10.4110/in.2011.11.6.399. Epub 2011 Dec 
      31.