PMID- 22349392
OWN - NLM
STAT- MEDLINE
DCOM- 20130606
LR  - 20120221
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 37
IP  - 1
DP  - 2012 Jan
TI  - [Effect of Gingkgo biloba leaf extract induced delayed preconditioning on 
      cytochrome c oxidase expression during myocardial ischemia-reperfusion in rats].
PG  - 89-93
LID - 10.3969/j.issn.1672-7347.2012.01.016 [doi]
AB  - OBJECTIVE: To determine the effect of Gingkgo biloba leaf extract (EGb761) 
      induced delayed preconditioning on cytochrome c oxidase (CcO) expression during 
      myocardial ischemia-reperfusion in rats. METHODS: Four groups (10 in each) of 
      Sprague-Dawley male rats were studied. In the sham group, the rats received no 
      treatment. Rats in the ischemia-reperfusion (IR) group were treated with NS (1.0 
      mL/kg intravenously) 24 h before ischemia. Rats in the M group were treated with 
      EGb761 (100 mg/kg intravenously) 24 h before the ischemia. In the D group , 
      EGb761-treated rats that received the 5-hydroxydecanoate (5-HD), an inhibitor of 
      mitochondrial KATP channels 15 min before the ischemia. The IR, M, and D groups 
      were subjected to ischemia by 30 min of coronary artery occlusion before 2 h of 
      reperfusion. At the end of the reperfusion, myocardial infarct size was measured. 
      CcO was measured by Western blot. The myocardial ultrastructure was observed 
      under the electron microscope. RESULTS: The infarct size was significantly 
      smaller in the M group [(23.78 +/- 4.82)%] than in the I/R group [(37.87 +/- 5.92)%] 
      (P<0.05). The CcO protein expression in the myocardium was significantly higher 
      in the M group than in the I/R group(P<0.05). Microscopic examination showed less 
      myocardial damage in the M group than that in the I/R group. The infarct size, 
      CcO protein expression, and myocardial damage had no significant difference 
      between the D group and the I/R group (P>0.05). CONCLUSION: EGb761 induced 
      delayed preconditioning attenuates myocardial ischemia-reperfusion injury 
      possibly through up-regulating CcO expression in rats.
FAU - Ran, Ke
AU  - Ran K
AD  - Department of Anesthesiology, Second Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - Wan, Jingjing
AU  - Wan J
FAU - Yang, Donglin
AU  - Yang D
FAU - Xiao, Yanying
AU  - Xiao Y
FAU - Chang, Yetian
AU  - Chang Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0 (Drugs, Chinese Herbal)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Animals
MH  - Drugs, Chinese Herbal/*pharmacology/therapeutic use
MH  - Electron Transport Complex IV/*metabolism
MH  - Ginkgo biloba/*chemistry
MH  - Ischemic Postconditioning/methods
MH  - Ischemic Preconditioning, Myocardial/*methods
MH  - Male
MH  - Myocardial Ischemia/physiopathology
MH  - Myocardial Reperfusion Injury/metabolism/*prevention & control
MH  - Phytotherapy
MH  - Plant Leaves/chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2012/02/22 06:00
MHDA- 2013/06/07 06:00
CRDT- 2012/02/22 06:00
PHST- 2012/02/22 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2013/06/07 06:00 [medline]
AID - 10.3969/j.issn.1672-7347.2012.01.016 [doi]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Jan;37(1):89-93. doi: 
      10.3969/j.issn.1672-7347.2012.01.016.