PMID- 22349614
OWN - NLM
STAT- MEDLINE
DCOM- 20130111
LR  - 20220410
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 11
IP  - 11
DP  - 2012 Sep
TI  - CD5 expression promotes multiple intracellular signaling pathways in B 
      lymphocyte.
PG  - 795-8
LID - 10.1016/j.autrev.2012.02.007 [doi]
AB  - CD5(+) B lymphocytes have distinct functional properties compared with B 
      lymphocytes that lack CD5. However, it remains unclear if and how the CD5 
      molecule modulates B lymphocyte biology and responses. Our recent studies have 
      revealed that CD5 promotes constitutive activation of multiple signaling pathways 
      including extracellular signal-regulated kinases (ERK1/2), phosphatidylinositol 
      3-kinase (PI-3K)/mammalian target of rapamycin (mTOR) and calcineurin-NFAT 
      signaling pathways. Further, changes in cytokine production including the 
      production of IL-10 are related to the activation of the transcription factors 
      NFAT2 and STAT3. All in all, these studies provide a framework for understanding 
      how CD5 impacts B lymphocyte biology and responses.
CI  - Copyright (c) 2012. Published by Elsevier B.V.
FAU - Mageed, Rizgar A
AU  - Mageed RA
AD  - Queen Mary University of London, William Harvey Research Institute, UK. 
      r.a.mageed@qmul.ac.uk
FAU - Garaud, Soizic
AU  - Garaud S
FAU - Taher, Taher E
AU  - Taher TE
FAU - Parikh, Kaushal
AU  - Parikh K
FAU - Pers, Jacques-Olivier
AU  - Pers JO
FAU - Jamin, Christophe
AU  - Jamin C
FAU - Renaudineau, Yves
AU  - Renaudineau Y
FAU - Youinou, Pierre
AU  - Youinou P
LA  - eng
GR  - 19528/FWF_/Austrian Science Fund FWF/Austria
PT  - Journal Article
PT  - Review
DEP - 20120212
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
RN  - 0 (CD5 Antigens)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - B-Lymphocytes/immunology/*metabolism
MH  - CD5 Antigens/genetics/*metabolism
MH  - Gene Expression Regulation
MH  - Humans
MH  - Protein Isoforms
MH  - Signal Transduction/*physiology
EDAT- 2012/02/22 06:00
MHDA- 2013/01/12 06:00
CRDT- 2012/02/22 06:00
PHST- 2012/02/22 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2013/01/12 06:00 [medline]
AID - S1568-9972(12)00028-6 [pii]
AID - 10.1016/j.autrev.2012.02.007 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2012 Sep;11(11):795-8. doi: 10.1016/j.autrev.2012.02.007. Epub 
      2012 Feb 12.