PMID- 22349746
OWN - NLM
STAT- MEDLINE
DCOM- 20121030
LR  - 20220318
IS  - 1438-8359 (Electronic)
IS  - 0913-8668 (Linking)
VI  - 26
IP  - 3
DP  - 2012 Jun
TI  - IV paracetamol effect on propofol-ketamine consumption in paediatric patients 
      undergoing ESWL.
PG  - 351-6
LID - 10.1007/s00540-012-1335-4 [doi]
AB  - PURPOSE: Electroshock wave lithotripsy (ESWL) is a painful procedure performed 
      with sedoanalgesia in paediatric patients. The propofol-ketamine combination may 
      be the preferable anaesthesia for this procedure, and propofol-ketamine 
      consumption may be decreased with the administration of intravenous (IV) 
      paracetamol. In this study we investigated the effect of IV paracetamol 
      administration on propofol-ketamine consumption, recovery time and frequency of 
      adverse events in paediatric patients undergoing ESWL. METHODS: Sixty children, 
      ranging in age from 1 to 10 years and with American Society of Anesthesiologists 
      Physical Status 1-2, were included in this prospective, randomized, 
      double-blinded study. Thirty minutes prior to the procedure children randomly 
      assigned to Group I received IV 15 mg/kg paracetamol, and those randomly assigned 
      to Group II received 1.5 mL/kg IV saline infusion 30 min. The propofol-ketamine 
      combination was prepared by mixing 25 mg propofol and 25 mg ketamine in a total 
      10 mL solution in the same syringe. After the administration of 0.1 mg/kg 
      midazolam and 10 mug/kg atropine to both groups and during the procedure, the 
      propofol-ketamine combination was administered at 0.5 mg/kg doses to achieve a 
      Wisconsin sedation score of 1 or 2. Oxygen saturation and heart rate were 
      recorded at 5-min intervals. Propofol-ketamine consumption, recovery times and 
      adverse events were also recorded. RESULTS: Demographic data were similar between 
      groups. Propofol-ketamine consumption (Group I, 25.2 +/- 17.7 mg; Group II, 35.4 +/- 
      20.1 mg; p = 0.04) and recovery times (Group I, 19.4 +/- 7.9 min; Group II, 29.6 +/- 
      11.4 min; p < 0.0001) were significantly different between groups. Saturation, 
      heart rate and adverse events were similar in both groups. CONCLUSION: Our data 
      suggest that the administration of IV paracetamol decreases propofol-ketamine 
      consumption for adequate sedation during ESWL procedures in paediatric patients 
      and shortens recovery time.
FAU - Eker, H Evren
AU  - Eker HE
AD  - Department of Anaesthesiology, Baskent University, Dadaloglu, Turkey. 
      evreneker@yahoo.com
FAU - Cok, Oya Yalcin
AU  - Cok OY
FAU - Ergenoglu, Pinar
AU  - Ergenoglu P
FAU - Aribogan, Anis
AU  - Aribogan A
FAU - Arslan, Gulnaz
AU  - Arslan G
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120217
PL  - Japan
TA  - J Anesth
JT  - Journal of anesthesia
JID - 8905667
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Anesthetics)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 690G0D6V8H (Ketamine)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Acetaminophen/*administration & dosage
MH  - Analgesics, Non-Narcotic/*administration & dosage
MH  - Anesthetics/*administration & dosage
MH  - Child
MH  - Child, Preschool
MH  - Double-Blind Method
MH  - Humans
MH  - Infant
MH  - Injections, Intravenous
MH  - Ketamine/*administration & dosage
MH  - *Lithotripsy
MH  - Propofol/*administration & dosage
MH  - Prospective Studies
EDAT- 2012/02/22 06:00
MHDA- 2012/10/31 06:00
CRDT- 2012/02/22 06:00
PHST- 2011/03/26 00:00 [received]
PHST- 2012/01/15 00:00 [accepted]
PHST- 2012/02/22 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/10/31 06:00 [medline]
AID - 10.1007/s00540-012-1335-4 [doi]
PST - ppublish
SO  - J Anesth. 2012 Jun;26(3):351-6. doi: 10.1007/s00540-012-1335-4. Epub 2012 Feb 17.